Evidence map›Paper›PMID 35896389›Full record

ArticleeNeuro

Neurofilament Transport Is Bidirectional

Nicholas P Boyer, Jean-Pierre Julien, Peter Jung, Anthony Brown

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Neurofilaments in health and Charcot-Marie-Tooth disease.Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nicholas P BoyerDepartment of Neuroscience, The Ohio State University, Columbus, Ohio 43210.
Jean-Pierre JulienDepartment of Psychiatry and Neuroscience, CERVO Brain Research Centre, University Laval, Québec City, QC G1J 2G3, Canada.
Peter JungDepartment of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio 45701.ORCID https://orcid.org/0000-0002-1100-9946
Anthony BrownDepartment of Neuroscience, The Ohio State University, Columbus, Ohio 43210 brown.2302@osu.edu.ORCID https://orcid.org/0000-0003-2295-2929
The Ohio State University · USOhio University · USUniversité Laval · CA

Funding

AXONAL TRANSPORT OF NEUROFILAMENTSR01NS038526 · NINDS · OHIO UNIVERSITY ATHENS · PI BROWN, ANTHONY · 1999 to 2018
$5.4M
Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2017 to 2020
$1.9M
A spinning disk confocal microscope for live-cell imagingS10OD010383 · OD · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2012 to 2012
$600k
NIH HHS S10 OD010383NINDS NIH HHS P30 NS104177NINDS NIH HHS R01 NS038526
6 · The paper itself

Abstract

Neurofilaments are abundant space-filling cytoskeletal polymers that are transported into and along axons. During postnatal development, these polymers accumulate in myelinated axons causing an expansion of axon caliber, which is necessary for rapid electrical transmission. Studies on cultured nerve cells have shown that axonal neurofilaments move rapidly and intermittently along microtubule tracks in both anterograde and retrograde directions. However, it is unclear whether neurofilament transport is also bidirectional

Indexed as

Axonal TransportIntermediate FilamentsAnimalsAxonsMiceNeurofilament ProteinsNeuronsNeurofilament Proteinsaxonaxonal transportgreen fluorescent proteinneurofilamentphotoactivation

Identifiers

PMID35896389
PMCPMC9410771
OpenAlexW4288074831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.