Evidence map›Paper›PMID 35896375›Full record

ArticlePractical neurology2022

Tumour-induced osteomalacia: a rare cause of chronic pain and weakness.

John T Nasr, Jack Tohme, Michael T Collins, Matthew T Drake, Iris R Hartley, Jad Sfeir, Keith Dockery, Metin Taskin

Abstract readCase Reports
In one paragraph

Article in Practical neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

John T NasrNeuroscience, Valley Hospital, Ridgewood, New Jersey, USA jnasr@neurobergen.com.ORCID http://orcid.org/0000-0003-0130-2177
Jack TohmeEndocrinology, Valley Hospital, Ridgewood, New Jersey, USA.
Michael T CollinsSkeletal Diseases and Mineral Homeostasis Section of NIDCR Disorders, National Institutes of Health, Bethesda, Maryland, USA.
Matthew T DrakeEndocrinology, Mayo Clinic, Rochester, Minnesota, USA.
Iris R HartleySkeletal Diseases and Mineral Homeostasis Section of NIDCR Disorders, National Institutes of Health, Bethesda, Maryland, USA.
Jad SfeirEndocrinology, Mayo Clinic, Rochester, Minnesota, USA.
Keith DockeryDiagnostic Imaging, Valley Hospital, Ridgewood, New Jersey, USA.
Metin TaskinPathology, Valley Hospital, Ridgewood, New Jersey, USA.
Valley Hospital · USMayo Clinic · USNational Institutes of Health · US

Funding

Skeletal Disorders and Mineral Homeostasis SectionZIADE000649 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI COLLINS, MICHAEL · 2009 to 2025
$32.8M
Intramural NIH HHS Z99 DE999999
6 · The paper itself

Abstract

Tumor-induced osteomalacia is a rare and often misdiagnosed condition that presents with progressively worsening unexplained chronic pain and proximal muscle weakness. The osteomalacia leads to multiple stress fractures which do not heal properly, leading to progressive disability. It is caused by chronic hypophosphatemia due to inappropriate urinary phosphate wasting. This is due to a typically benign mesenchymal tumor that over-secretes a phospaturic hormone. Neurologists need to appreciate the relevance of chronic hypophosphatemia in people with chronic unexplained pain, as timely diagnosis and treatment of tumour-induced osteomalacia can be curative.

Indexed as

Chronic PainHypophosphatemiaNeoplasms, Connective TissueOsteomalaciaParaneoplastic SyndromesHumansCLINICAL NEUROLOGYMETABOLIC DISEASENEUROENDOCRINOLOGYPAIN

Identifiers

PMID35896375
PMCPMC13191607
OpenAlexW4288074783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.