Evidence map›Paper›PMID 35896368›Full record

ArticleStem cells (Dayton, Ohio)2022

Single-Cell RNA-Seq Identifies Dynamic Cardiac Transition Program from ADCs Induced by Leukemia Inhibitory Factor.

Jiayi Yao, Feiyang Ma, Li Zhang, Ching Zhu, Medet Jumabay, Zehao Yao, Lumin Wang, Xinjiang Cai, Daoqin Zhang, Xiaojing Qiao and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells (Dayton, Ohio), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Jiayi YaoDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Feiyang MaMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6260-0787
Li ZhangDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-2638-2919
Ching ZhuDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Medet JumabayDivision of Allergy, Immunology Center for Immunity, Infection, and Inflammation Pediatrics, Dept of Medicine, University of California, San Diego, San Diego, CA, USA.
Zehao YaoPeking Union Medical College, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People's Republic of China.
Lumin WangInstitute of Precision Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Xinjiang CaiDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Daoqin ZhangDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Xiaojing QiaoDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Kalyanam ShivkumarDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Matteo PellegriniMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Yucheng YaoDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Xiuju WuDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Kristina I BoströmDivision of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7745-5025
University of California, Los Angeles · USChinese Academy of Medical Sciences & Peking Union Medical College · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNUniversity of California San Diego · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
Molecular Mechanisms of MGP; Role in AVMsR01HL081397 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2006 to 2025
$7.7M
BMP and Notch Crosstalk in Cerebral Arteriovenous MalformationsR01NS079353 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2012 to 2026
$5.3M
Switch of Osteogenesis in Vascular CalcificationR01HL139675 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2018 to 2026
$3.6M
Endothelial Regulation of Vascular CalcificationR01HL158053 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2022 to 2025
$2.2M
Erasing ill features of arterial endothelial cells in hereditary hemorrhagic telangiectasiaR01HL162643 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YAO, YUCHENG · 2022 to 2025
$1.6M
Role of The Endothelium In Vascular CalcificationR01HL112839 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2013 to 2016
$1.5M
NHLBI NIH HHS HL139675NHLBI NIH HHS HL30568NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL081397NHLBI NIH HHS R01 HL112839NHLBI NIH HHS R01 HL139675NHLBI NIH HHS R01 HL158053NHLBI NIH HHS R01 HL162643NHLBI NIH HHS T32 HL007895NIH HHS T32HL007895NINDS NIH HHS NS79353NINDS NIH HHS R01 NS079353
6 · The paper itself

Abstract

Adipose-derived cells (ADCs) from white adipose tissue are promising stem cell candidates because of their large regenerative reserves and the potential for cardiac regeneration. However, given the heterogeneity of ADC and its unsolved mechanisms of cardiac acquisition, ADC-cardiac transition efficiency remains low. In this study, we explored the heterogeneity of ADCs and the cellular kinetics of 39,432 single-cell transcriptomes along the leukemia inhibitory factor (LIF)-induced ADC-cardiac transition. We identified distinct ADC subpopulations that reacted differentially to LIF when entering the cardiomyogenic program, further demonstrating that ADC-myogenesis is time-dependent and initiates from transient changes in nuclear factor erythroid 2-related factor 2 (Nrf2) signaling. At later stages, pseudotime analysis of ADCs navigated a trajectory with 2 branches corresponding to activated myofibroblast or cardiomyocyte-like cells. Our findings offer a high-resolution dissection of ADC heterogeneity and cell fate during ADC-cardiac transition, thus providing new insights into potential cardiac stem cells.

Indexed as

Myocytes, CardiacNF-E2-Related Factor 2Cell DifferentiationLeukemia Inhibitory FactorRNA-SeqLeukemia Inhibitory FactorNF-E2-Related Factor 2ADCadiposecardiac transitioncell sequencingderived cellsleukemia inhibitory factor (LIF)single

Identifiers

PMID35896368
PMCPMC9585902
OpenAlexW4288060257

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.