Evidence map›Paper›PMID 35896306›Full record

ArticleBMJ case reports2022

Paediatric acute respiratory distress syndrome: consider the role of lymphatics.

Mimi Lu, Elena Cavazzoni, Hiran Selvadurai, Juerg Martin Burren

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Octreotide and direct/indirect lung injury.Research in pharmaceutical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mimi LuRespiratory and Sleep Department, Children's Hospital at Westmead, Westmead, New South Wales, Australia mimi.lu1@health.nsw.gov.au.ORCID http://orcid.org/0000-0002-1590-0285
Elena CavazzoniPaediatric Intensive Care Unit, Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Hiran SelvaduraiRespiratory and Sleep Department, Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Juerg Martin BurrenPaediatric Intensive Care Unit, Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID http://orcid.org/0000-0003-1744-505X
Children's Hospital at Westmead · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a 7-day-old male infant with severe respiratory disease requiring venoarterial extracorporeal membrane oxygenation therapy with evidence of lymphangiectasia on lung biopsy. Differentiating primary versus secondary lymphangiectasis in this patient remains a riddle despite extensive investigations including an infective screen, lung biopsy and whole-genome sequencing. In addition to the standard therapies used in paediatric acute respiratory distress syndrome, such as lung-protective ventilation, permissive hypoxaemia and hypercarbia, nursing in the prone position, early use of muscle relaxants, rescue intravenous corticosteroids and broad-spectrum antibiotics, the patient was also given octreotide despite the absence of a chylothorax based on the theoretical benefit of altering the lymphatic flow. His case raises an interesting discussion around the role of lymphatics in the pathophysiology of paediatric and adult respiratory distress syndrome and prompts the exploration of novel agents which may affect lymphatic vessels used as an adjunctive therapy.

Indexed as

Extracorporeal Membrane OxygenationLymphangiectasisLymphatic VesselsRespiratory Distress SyndromeAdultChildHumansInfantMaleProne PositionRespiration, ArtificialPaediatric intensive carePaediatricsRespiratory medicine

Identifiers

PMID35896306
PMCPMC9335033
OpenAlexW4288457163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.