Evidence map›Paper›PMID 35896044›Full record

ArticleHearing research2022

Audiologic characterization using clinical physiological measures: Normative data from macaque monkeys.

Amy N Stahl, Jane A Mondul, Katy A Alek, Troy A Hackett, Ramnarayan Ramachandran

Open access · greenAbstract read
In one paragraph

Article in Hearing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Developing a Calibration Method to Minimize Variability in Auditory Evoked Potentials.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amy N StahlVanderbilt Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37212; Vanderbilt Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37212. Electronic address: amy.n.stahl@vanderbilt.edu.
Jane A MondulVanderbilt Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37212; Vanderbilt Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37212. Electronic address: jane.a.burton@vanderbilt.edu.
Katy A AlekVanderbilt Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37212. Electronic address: Catherine.a.alek@vumc.org.
Troy A HackettVanderbilt Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37212. Electronic address: troy.a.hackett@vanderbilt.edu.
Ramnarayan RamachandranVanderbilt Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37212. Electronic address: ramnarayan.ramachandran@vumc.org.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Physiological Signatures and Behavioral Correlates of Hidden Hearing LossR01DC015988 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAMACHANDRAN, RAMNARAYAN, SHINN-CUNNINGHAM, BARBARA · 2018 to 2022
$3.5M
Physiological and Perceptual Assessment of Hearing in Noise in Nonhuman Primates Following Noise-Induced Cochlear SynaptopathyF32DC019817 · NIDCD · VANDERBILT UNIVERSITY · PI MONDUL, JANE ANN · 2021 to 2022
$81k
NICHD NIH HHS P50 HD103537NIDCD NIH HHS F32 DC019817NIDCD NIH HHS R01 DC015988
6 · The paper itself

Abstract

Clinical auditory physiological measures (e.g., auditory brainstem responses, ABRs, and distortion product otoacoustic emissions, DPOAEs) provide diagnostic specificity for differentially diagnosing overt hearing impairments, but they remain limited in their ability to detect specific sites of lesion and subtle levels of cochlear damage. Studies in animal models may hold the key to improve differential diagnosis due to the ability to induce tightly controlled and histologically verifiable subclinical cochlear pathologies. Here, we present a normative set of traditional and clinically novel physiological measures using ABRs and DPOAEs measured in a large cohort of male macaque monkeys. Given the high similarities between macaque and human auditory anatomy, physiology, and susceptibility to hearing damage, this normative data set will serve as a crucial baseline to investigate novel physiological measures to improve diagnostics. DPOAE amplitudes were robust at f

Indexed as

MacacaOtoacoustic Emissions, SpontaneousAnimalsAuditory ThresholdEvoked Potentials, Auditory, Brain StemHaplorhiniHumansMaleReproducibility of Resultsauditory brainstem responsedistortion product otoacoustic emissionselectrophysiologynonhuman primatesperipheral auditory functionPhysiology

Identifiers

PMID35896044
PMCPMC9529828
OpenAlexW4285045678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.