Evidence map›Paper›PMID 35895919›Full record

ArticleJournal of environmental science and health. Part C, Toxicology and carcinogenesis2022

Longitudinal association of early childhood lead exposure and adolescent heart rate variability: influence of parental education.

Olivia M Halabicky, Jennifer A Pinto-Martin, Peggy Compton, Jianghong Liu

Open access · greenAbstract read
In one paragraph

Article in Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Olivia M HalabickySchool of Nursing, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7386-1467
Jennifer A Pinto-MartinSchool of Nursing, University of Pennsylvania, Philadelphia, PA, USA.
Peggy ComptonSchool of Nursing, University of Pennsylvania, Philadelphia, PA, USA.
Jianghong LiuSchool of Nursing, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2528-9931
University of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
Omega-3 Supplementation and Adolescent BehaviorR01HD087485 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG, RAINE, ADRIAN · 2017 to 2021
$2.5M
Lead exposure, externalizing behavior, and neurobiological mediating factorsR01ES018858 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2010 to 2014
$1.7M
Mechanisms that mediate the link between lead exposure and child behavior problemK02ES019878 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2011 to 2015
$656k
Environmental Toxicity, Malnutrition, and Children's Externalizing BehaviorK01ES015877 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, JIANGHONG · 2007 to 2010
$605k
Pre-op CBT to Reduce the Risk for Development of Chronic Post-surgical Pain in Patients undergoing Total Knee ArthroplastyR21NR019047 · NINR · UNIVERSITY OF PENNSYLVANIA · PI CHEATLE, MARTIN D, COMPTON, PEGGY A · 2020 to 2021
$446k
Effect of opioid taper on pain responses in patients with chronic painR21DA046364 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI COMPTON, PEGGY A · 2019 to 2020
$443k
Environmental and Biological Influences on Child Health: Examining the Effects of Lead Exposure and Social Risk Factors on NeurocognitionF31NR019527 · NINR · UNIVERSITY OF PENNSYLVANIA · PI HALABICKY, OLIVIA MARYFRANCES · 2020 to 2020
$42k
NICHD NIH HHS R01 HD087485NIDA NIH HHS R21 DA046364NIEHS NIH HHS K01 ES015877NIEHS NIH HHS K02 ES019878NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES018858NIEHS NIH HHS T32 ES007062NINR NIH HHS F31 NR019527NINR NIH HHS R21 NR019047
6 · The paper itself

Abstract

Lead exposure has been shown to dysregulate physiological stress responses. However, few studies have investigated the effect of lead exposure on later heart rate variability (HRV), an indicator of a stress response, in large samples of children. Furthermore, the interaction between social environmental factors and lead exposure in childhood, which commonly co-occur, remains understudied. This study examined relationships between childhood lead exposure and early adolescent physiological stress responses at different levels of parental education. Participants were 406 children from Jintan, China. Blood lead levels (BLLs) and parental education data were collected at 3-5 years of age, and HRV outcomes assessed at 12 years via frequency domain measures (LF/HF ratio) collected during an induced stress test. Results show a significant interaction between parental education and BLLs at 3-5 years. This relationship was found to be most consistent for the interaction between BLLs and mother's years of education for both the planning (

Indexed as

LeadStress, PhysiologicalAdolescentChildChild, PreschoolChinaHeart RateHumansLeadBlood lead levelschild developmentheart rate variabilityparental educationphysiological stresssocial environmental factor

Identifiers

PMID35895919
PMCPMC9339516
OpenAlexW4288057627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.