ArticleScience advances2022
Through-skull brain imaging in vivo at visible wavelengths via dimensionality reduction adaptive-optical microscopy.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Rapid wavefront shaping using an optical gradient acquisition.Nature communications · 2026Article
- Matrix-based imaging through dynamic scattering.Nature communications · 2025Article
- Rapid in situ microwave-assisted fabrication of ultrabright near-infrared probe for low-dose in vivo inflammatory imaging.Journal of nanobiotechnology · 2025Article
- Digital aberration correction for enhanced thick tissue imaging exploiting aberration matrix and tilt-tilt correlation from the optical memory effect.Nature communications · 2025Article
- Long-term tracking of neural and oligodendroglial development in large-scale human cerebral organoids by noninvasive volumetric imaging.Scientific reports · 2025Article
- Noninvasive megapixel fluorescence microscopy through scattering layers by a virtual incoherent reflection matrix.Science advances · 2024Article
- Phase contrast reflectance confocal brain imaging at 1650 nm.Journal of biomedical optics · 2024Article
- Tracing multiple scattering trajectories for deep optical imaging in scattering media.Nature communications · 2023Article
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Authors and funding
8 authors.
Funding
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Abstract
Compensation of sample-induced optical aberrations is crucial for visualizing microscopic structures deep within biological tissues. However, strong multiple scattering poses a fundamental limitation for identifying and correcting the tissue-induced aberrations. Here, we introduce a label-free deep-tissue imaging technique termed dimensionality reduction adaptive-optical microscopy (DReAM) to selectively attenuate multiple scattering. We established a theoretical framework in which dimensionality reduction of a time-gated reflection matrix can attenuate uncorrelated multiple scattering while retaining a single-scattering signal with a strong wave correlation, irrespective of sample-induced aberrations. We performed mouse brain imaging in vivo through the intact skull with the probe beam at visible wavelengths. Despite the strong scattering and aberrations, DReAM offered a 17-fold enhancement of single scattering-to-multiple scattering ratio and provided high-contrast images of neural fibers in the brain cortex with the diffraction-limited spatial resolution of 412 nanometers and a 33-fold enhanced Strehl ratio.
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Registered trials
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