ArticleScience advances2022
Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A minimal hybridization capture approach for the parallel enrichment and cost-effective detection of ancient human pathogens.iScience · 2026Article
- Genome-wide analyses of an avian herpesvirus identify 10 loci associated with tumorigenicity and vaccine escape.Science advances · 2026Article
- Detangling knots: the intricate roles of G-quadruplexes in herpesvirus replication.Journal of virology · 2026Review
- Phylogenetic and Genomic Characterization of Whole Genome Sequences of a Herpes Simplex Virus Type 1 Isolate Identified Genomic Variant Characteristics in a Human Subject with Fulminant Hepatitis.International journal of molecular sciences · 2026Article
- Recovery and analysis of ancient DNA: challenges, methods, and applications in forensic and archaeological science.Journal, genetic engineering & biotechnology · 2026Article
- Insights into infectious diseases through ancient pathogen genomics.Nature reviews. Microbiology · 2026Review
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNA.Science advances · 2026Article
- Ancient DNA insights into diverse pathogens and their hosts.Nature reviews. Genetics · 2026Review
- The evolutionary origin of the collective unconscious and the appeal of research on Neanderthals and other ancient humans.Frontiers in psychology · 2026Article
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- Genome evolution of Kaposi sarcoma-associated herpesvirus (KSHV).Journal of virology · 2025Article
- Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency.bioRxiv : the preprint server for biology · 2025Article
- Population Genetic Structure and Human Adaptation of Kaposi Sarcoma-Associated Herpesvirus.Open forum infectious diseases · 2025Article
- Statistical Distributions of Genome Assemblies Reveal Random Effects in Ancient Viral DNA Reconstructions.Viruses · 2025Article
- Decoding and Unravelling Mpox, Herpes, and Syphilis Infections: A State of Art Review.Current pharmaceutical biotechnology · 2025Review
- Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL31.6 of herpes simplex virus 1.Journal of virology · 2024Article
- Article
- Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.Nature · 2024Article
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21 authors.
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Abstract
Human herpes simplex virus 1 (HSV-1), a life-long infection spread by oral contact, infects a majority of adults globally. Phylogeographic clustering of sampled diversity into European, pan-Eurasian, and African groups has suggested the virus codiverged with human migrations out of Africa, although a much younger origin has also been proposed. We present three full ancient European HSV-1 genomes and one partial genome, dating from the 3rd to 17th century CE, sequenced to up to 9.5× with paired human genomes up to 10.16×. Considering a dataset of modern and ancient genomes, we apply phylogenetic methods to estimate the age of sampled modern Eurasian HSV-1 diversity to 4.68 (3.87 to 5.65) ka. Extrapolation of estimated rates to a global dataset points to the age of extant sampled HSV-1 as 5.29 (4.60 to 6.12) ka, suggesting HSV-1 lineage replacement coinciding with the late Neolithic period and following Bronze Age migrations.
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