ArticleScience advances2022
Presynaptic supervision of cortical spine dynamics in motor learning.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Alternative microexon splicing code for a four-amino acid peptide of PTPRD governs behavioral development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Functional synaptic connectivity shapes spine stability in the hippocampus.Nature communications · 2026Article
- Article
- Learning and Control in Motor Cortex across Cell Types and Scales.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Identification of a Hippocampus-to-Zona Incerta Projection involved in Motor Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cortico-basal ganglia plasticity in motor learning.Neuron · 2024Review
- Synaptic correlates of the corticocortical circuit in motor learning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective.Anatomical science international · 2024Review
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits.Advances in neurobiology · 2023Article
- Cortical circuit dynamics underlying motor skill learning: from rodents to humans.Frontiers in molecular neuroscience · 2023Review
- Dendritic Spines in Learning and Memory: From First Discoveries to Current Insights.Advances in neurobiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammalian neocortex, learning triggers the formation and turnover of new postsynaptic spines on pyramidal cell dendrites. However, the biological principles of spine reorganization during learning remain elusive because the identity of their presynaptic neuronal partners is unknown. Here, we show that two presynaptic neural circuits supervise distinct programs of spine dynamics to execute learning. We imaged spine dynamics in motor cortex during learning and performed post hoc identification of their afferent presynaptic neurons. New spines that appeared during learning formed small transient contacts with corticocortical neurons that were eliminated on skill acquisition. In contrast, persistent spines with axons from thalamic neurons were formed and enlarged. These results suggest that pyramidal cell dendrites in motor cortex use a neural circuit division of labor during skill learning, with dynamic teaching contacts from top-down intracortical axons followed by synaptic memory formation driven by thalamic axons. Dual spine supervision may govern diverse skill learning in the neocortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.