Evidence map›Paper›PMID 35895618›Full record

ArticlePloS one2022

Impact of preoperative anemia, iron-deficiency and inflammation on survival after colorectal surgery-A retrospective cohort study.

Messina Bath, André Viveiros, Benedikt Schaefer, Sebastian Klein, Lorenz M Pammer, Sonja Wagner, Andreas Lorenz, Christopher Rugg, Elisabeth Gasser, Marijana Ninkovic and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06049693 (Iron Prehabilitation and Perioperative Infectious Diseases of Endometrial Cancer Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06049693 phase4completednot on this mapstarted 2023, after this paper: background citation

Iron Prehabilitation and Perioperative Infectious Diseases of Endometrial Cancer Patients

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2023 to 2024Enrolled156ConditionsEndometrial Cancer, Perioperative Complication, PrehabilitationArmsFerrous Gluconate 300 MG
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Messina BathChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
André ViveirosChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
Benedikt SchaeferChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
Sebastian KleinDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.
Lorenz M PammerChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-9228-372X
Sonja WagnerChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
Andreas LorenzDepartment of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-2498-1806
Christopher RuggDepartment of Anaesthesiology and Intensive care, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.
Elisabeth GasserDepartment of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.
Marijana NinkovicDepartment of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.
Marlene PanzerChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
Elke PertlerChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
Dietmar FriesDepartment of Anaesthesiology and Intensive care, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.
Herbert TilgDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.
Guenter WeissDepartment of Medicine II, Infectious Diseases, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.
Verena PetzerDepartment of Medicine V, Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Dietmar Öfner-VelanoDepartment of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, University Hospital & Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-8909-8566
Heinz ZollerChristian Doppler Laboratory on Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-1794-422X
Universität Innsbruck · ATInnsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnemia is present in up to two-thirds of patients undergoing colorectal surgery mainly caused by iron deficiency and inflammation. As anemia is associated with increased risk of perioperative death, diagnosis and treatment of preoperative anemia according to etiology have been recommended.

objectiveThe aim of the present study was to assess if the association between anemia and survival in patients undergoing colorectal surgery was determined by the severity of anemia alone or also by anemia etiology.

methodsTo determine the prevalence of anemia and etiology, preoperative hematological parameters, C-reactive protein, ferritin and transferrin saturation were retrospectively assessed and correlated with outcome in a cohort of patients undergoing colorectal surgery between 2005 and 2019 at the University Hospital of Innsbruck. Anemia was defined as hemoglobin <120 g/L in females and <130 g/L in males. The etiology of anemia was classified on the basis of serum iron parameters, as iron deficiency anemia, anemia of inflammation or other anemia etiologies.

resultsPreoperative anemia was present in 54% (1316/2458) of all patients. Anemia was associated with iron deficiency in 45% (134/299) and classified as anemia of inflammation in 32% (97/299) of patients with available serum iron parameters. The etiology of anemia was a strong and independent predictor of survival, where iron deficiency and anemia of inflammation were associated with better postoperative survival than other anemia etiologies. One year survival rates were 84.3%, 77.3% and 69.1% for patients with iron deficiency anemia, anemia of inflammation and other anemia types. Inflammation indicated by high C-reactive protein is a strong negative predictor of overall survival.

conclusionsAnemia has a high prevalence among patients undergoing colorectal surgery and rational treatment requires early assessment of serum iron parameters and C-reactive protein.

Indexed as

AnemiaAnemia, Iron-DeficiencyColorectal SurgeryIron DeficienciesCohort StudiesC-Reactive ProteinFemaleHemoglobinsHumansInflammationIronMaleRetrospective StudiesC-Reactive ProteinHemoglobinsIron

Identifiers

PMID35895618
PMCPMC9328530
OpenAlexW4288051749

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.