Evidence map›Paper›PMID 35895585›Full record

ArticleThe American journal of tropical medicine and hygiene2022

Case Report: The First Case Report of Visceral Leishmaniasis in Cambodia.

Sam Lyvannak, Korb Sreynich, Sing Heng, Miliya Thyl, Arjun Chandna, Ngoun Chanpheaktra, Ngeth Pises, Prak Farrilend, Jason Jarzembowski, Vasiliki Leventaki and 7 more

Abstract readCase Reports
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Novel duplex TaqMan-based quantitative PCR for rapid and accurate diagnosis ofCurrent research in parasitology & vector-borne diseases · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sam LyvannakAngkor Hospital for Children, Siem Reap, Cambodia.
Korb SreynichAngkor Hospital for Children, Siem Reap, Cambodia.
Sing HengAngkor Hospital for Children, Siem Reap, Cambodia.
Miliya ThylAngkor Hospital for Children, Siem Reap, Cambodia.
Arjun ChandnaAngkor Hospital for Children, Siem Reap, Cambodia.
Ngoun ChanpheaktraAngkor Hospital for Children, Siem Reap, Cambodia.
Ngeth PisesAngkor Hospital for Children, Siem Reap, Cambodia.
Prak FarrilendAngkor Hospital for Children, Siem Reap, Cambodia.
Jason JarzembowskiMedical College of Wisconsin, Milwaukee, Wisconsin.
Vasiliki LeventakiMedical College of Wisconsin, Milwaukee, Wisconsin.
Jonathan DavickUniversity of Iowa, Iowa City, Iowa.
Cindy NeunertColumbia University, New York City, New York.
Frank KellerAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.
Leslie S KeanBoston Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.
Bruce CamittaMedical College of Wisconsin, Milwaukee, Wisconsin.
Katherine TarlockSeattle Children's Hospital, Seattle, Washington.
Benjamin WatkinsAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis is considered a neglected tropical disease that is commonly found in Asia, Africa, South America, and Mediterranean countries. Visceral leishmaniasis (VL) is the most severe form of the disease and is almost universally fatal if left untreated. The symptoms of VL overlap with many infectious diseases, malignancies, and other blood disorders. The most common findings include fever, cytopenias, and splenomegaly. Given the nonspecific symptoms, the diagnosis requires detailed laboratory investigations, including bone marrow examination, that can be challenging in low- and middle-income countries. Diagnostic limitations likely lead to the underdiagnosis or delay in diagnosis of VL. We describe, to our knowledge, the first case report of VL in Cambodia in a child presenting with fever, anemia, and thrombocytopenia. The diagnosis required a liver biopsy and multiple bone marrow biopsies to visualize intracellular Leishmania spp. Our case illustrates the diagnostic challenges and the importance of timely diagnosis. This case also highlights the need for heightened awareness of the diagnostic findings of VL and improved reporting of tropical diseases.

Indexed as

LeishmaniaLeishmaniasisLeishmaniasis, VisceralCambodiaChildFeverHumansSpleen

Identifiers

PMID35895585
PMCPMC9393436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.