Evidence map›Paper›PMID 35895506›Full record

ArticleNucleic acid therapeutics2022

Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of

Lorna Gcanga, Ousman Tamgue, Mumin Ozturk, Shandre Pillay, Raygaana Jacobs, Julius Ebua Chia, Stanley Kimbung Mbandi, Malika Davids, Keertan Dheda, Sebastian Schmeier and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acid therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. LncRNA-CFTBS enhancesVirulence · 2025
    Article
  4. Article
  5. Article
  6. Long non-coding RNA transcripts inNon-coding RNA research · 2025
    Review
  7. HNRNPA2B1: a novel target in pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2025
    Review
  8. Review
  9. Article
  10. Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 6 countries.

Lorna GcangaInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.
Ousman TamgueInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.
Mumin OzturkInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.
Shandre PillayInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.
Raygaana JacobsInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.
Julius Ebua ChiaInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.
Stanley Kimbung MbandiDivision of Immunology, Department of Pathology, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Malika DavidsDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa.
Keertan DhedaDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa.
Sebastian SchmeierCollege of Science, School of Natural and Computational Sciences, Massey University, Auckland, New Zealand.
Tanvir AlamInformation and Computing Technology Division, College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar.
Sugata RoyRIKEN Center for Integrative Medical Sciences, Cellular Function Conversion Technology Team, Yokohama, Japan.
Harukazu SuzukiRIKEN Center for Integrative Medical Sciences, Cellular Function Conversion Technology Team, Yokohama, Japan.
Frank BrombacherInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.
Reto GulerInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Department of Pathology, Cape Town Component, Cape Town, South Africa.ORCID 0000-0002-6894-2163
South African Medical Research Council · ZAUniversity of Cape Town · ZARIKEN Center for Integrative Medical Sciences · JPHamad bin Khalifa University · QAMassey University · NZ

Funding

Targeting non-coding RNAs as host-directed drug therapy for tuberculosisR01AI160501 · NIAID · UNIVERSITY OF CAPE TOWN · PI GULER, RETO, HIDE, WINSTON ALEXANDER · 2021 to 2025
$646k
NIAID NIH HHS R01 AI160501Wellcome Trust 203135
6 · The paper itself

Abstract

Tuberculosis (TB) caused by

Indexed as

Mycobacterium tuberculosisRNA, Long NoncodingTuberculosisAnimalsHost-Pathogen InteractionsHumansInterleukin-13Interleukin-4Leukocytes, MononuclearMiceOligonucleotides, AntisenseInterleukin-13Interleukin-4Oligonucleotides, AntisenseRNA, Long Noncodinghost-directed therapyinflammationlong noncoding RNAsmacrophagesM. tuberculosis

Identifiers

PMID35895506
PMCPMC7613730
OpenAlexW4288052052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.