Evidence map›Paper›PMID 35895440›Full record

ArticleTransfusion2022

Evidence of likely autochthonous Chagas disease in the southwestern United States: A case series of Trypanosoma cruzi seropositive blood donors.

Mary K Lynn, Kyndall C Dye-Braumuller, Norman L Beatty, Patricia L Dorn, Stephen A Klotz, Susan L Stramer, Rebecca L Townsend, Hany Kamel, Jacquelyn M Vannoy, Patrick Sadler and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Transfusion, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Pathogens (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Review
  8. Transmission risk of Trypanosoma cruzi through blood donors in a third-level care hospital.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025
    Article
  9. Review
  10. Genetic Diversity ofLife (Basel, Switzerland) · 2024
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Mary K LynnDepartment of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.ORCID 0000-0001-5549-3947
Kyndall C Dye-BraumullerDepartment of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Norman L BeattyDivision of Infectious Diseases & Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-3032-5741
Patricia L DornDepartment of Biological Sciences, Loyola University New Orleans, New Orleans, Louisiana, USA.
Stephen A KlotzDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Susan L StramerScientific Affairs, American Red Cross, Gaithersburg, Maryland, USA.ORCID 0000-0002-5865-6366
Rebecca L TownsendScientific Affairs, American Red Cross, Gaithersburg, Maryland, USA.
Hany KamelCorporate Medical Affairs, Vitalant, Scottsdale, Arizona, USA.
Jacquelyn M VannoyCorporate Medical Affairs, Vitalant, Scottsdale, Arizona, USA.
Patrick SadlerCentral California Blood Center, Fresno, California, USA.
Susan P MontgomeryDivision of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Hilda N RiveraDivision of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Melissa S NolanDepartment of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
University of South Carolina · USAmerican Red Cross · USCenters for Disease Control and Prevention · USUniversity of Arizona · USVitalant · USLoyola University New Orleans · USVA Central California Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChagas disease is a parasitic infection that can insidiously cause non-ischemic cardiomyopathy. Given the largely silent nature of this progressive disease, asymptomatic blood donors pose potential blood transfusion risk. Blood donation screening has become an unintentional form of Chagas disease surveillance, with thousands of new cases identified since national surveillance was initiated in 2007. STUDY DESIGN AND

methodsWe recruited T. cruzi-positive blood donors identified from California and Arizona blood centers for confirmatory blood screening and assessment of lifetime infection risk.

resultsAmong eight suspected cases, we identified four confirmed US autochthonous infections. The current manuscript details the transmission sources, healthcare-seeking behaviors post-blood donation resulting, and clinical course of disease among persons without any history of travel to endemic Latin American countries. DISCUSSION: This manuscript presents four additional US-acquired Chagas disease cases and identifies an opportunity for blood centers to assist in confronting barriers surrounding Chagas disease in the US.

Indexed as

Chagas DiseaseTrypanosoma cruziBlood DonorsBlood TransfusionHumansSouthwestern United Statesautochthonous Chagas diseaseChagas disease USATrypanosoma cruzi

Identifiers

PMID35895440
PMCPMC9543114
OpenAlexW4288052182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.