ArticleThe British journal of dermatology2022
Primary cutaneous peripheral T-cell lymphomas with a T-follicular helper phenotype: an integrative clinical, pathological and molecular case series study.
Article in The British journal of dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Primary Cutaneous Follicular Helper T-Cell Lymphoma: A Clinicopathological Study of Six Cases and Review of the Literature.Journal of cutaneous pathology · 2026Review
- Skin manifestations uncover underlying Follicular helper T-cell lymphoma, angioimmunoblastic-type in an immunosuppressed patient.Virchows Archiv : an international journal of pathology · 2026Article
- Article
- Primary Cutaneous Peripheral T-Cell Lymphoma With Follicular Helper T-Cell Phenotype.Journal of cutaneous pathology · 2026Article
- CXCL13 as a simple and promising blood biomarker for differentiating Sézary syndrome from mycosis fungoides and other confounding chronic inflammatory skin diseases.Frontiers in immunology · 2026Observational
- A Rare Case of Primary Cutaneous Epstein-Barr Virus-Positive T Follicular Helper Cell Lymphoma.Cureus · 2025Article
- Paediatric cutaneous lymphomas including rare subtypes: A 40-year experience at a tertiary referral centre.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Sézary syndrome with large cell transformation and T-follicular helper phenotype.JAAD case reports · 2024Article
- Update on primary cutaneous T-cell lymphomas rare subtypes.Dermatology reports · 2024Review
- Primary cutaneous T-follicular helper lymphoma.EJHaem · 2023Article
- Article
- Cutaneous T-cell lymphomas: 2023 update on diagnosis, risk-stratification, and management.American journal of hematology · 2023Article
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18 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPrimary cutaneous peripheral T-cell lymphomas with a T-follicular helper phenotype (pcTFH-PTCL) are poorly characterized, and often compared to, but not corresponding with, mycosis fungoides (MF), Sézary syndrome, primary cutaneous CD4
objectivesWe describe the clinicopathological features of pcTFH-PTCL in this original series of 23 patients, and also characterize these cases molecularly.
methodsClinical and histopathological data of the selected patients were reviewed. Patient biopsy samples were also analysed by targeted next-generation sequencing.
resultsAll patients (15 men, eight women; median age 66 years) presented with skin lesions, without systemic disease. Most were stage T3b, with nodular (n = 16), papular (n = 6) or plaque (atypical for MF, n = 1) lesions. Three (13%) developed systemic disease and died of lymphoma. Nine (39%) patients received more than one line of chemotherapy. Histologically, the lymphomas were CD4
conclusionsPatients with pcTFH-PTCL have pathological and genetic features that overlap with those of systemic lymphoma of TFH derivation. Clinically, most remained confined to the skin, with only three patients showing systemic spread and death. Whether pcTFH-PTCL should be integrated as a new subgroup of TFH lymphomas in future classifications is still a matter of debate. What is already known about this topic? There is a group of cutaneous lymphomas that express T-follicular helper (TFH) markers that do not appear to correspond to existing World Health Organization diagnostic entities. These include mycosis fungoides, Sézary syndrome, or primary cutaneous CD4
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