Evidence map›Paper›PMID 35895370›Full record

ArticleThe American journal of tropical medicine and hygiene2022

Case Report: Cambodian National Malaria Surveillance Program Detection of Plasmodium knowlesi.

Christina Yek, Sreyngim Lay, Jennifer A Bohl, Somnang Man, Sophana Chea, Chanthap Lon, Vida Ahyong, Cristina M Tato, Joseph L DeRisi, Siv Sovannaroth and 1 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Emerging malaria in Indonesia: An overview ofParasite epidemiology and control · 2025
    Article
  6. Tropical medicine and infectious disease · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Christina YekDepartment of Critical Care Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.
Sreyngim LayInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Phnom Penh, Cambodia.
Jennifer A BohlVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Somnang ManInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Phnom Penh, Cambodia.
Sophana CheaInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Phnom Penh, Cambodia.
Chanthap LonInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Phnom Penh, Cambodia.
Vida AhyongChan Zuckerberg Biohub, San Francisco, California.
Cristina M TatoChan Zuckerberg Biohub, San Francisco, California.
Joseph L DeRisiChan Zuckerberg Biohub, San Francisco, California.
Siv SovannarothNational Center of Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.
Jessica E ManningLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Chan Zuckerberg Initiative (United States) · USNational Institutes of Health · USCambodia National Malaria Center · KH

Funding

International Research in Cambodia: Tropical Medicine and Vector Research ZIAAI001066 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI YEK, CHRISTINA · 2009 to 2025
$10.8M
6 · The paper itself

Abstract

Despite recent success in reducing the regional incidence of Plasmodium falciparum malaria, cases of zoonotic malaria are on the rise in Southeast Asia. The Cambodian National Malaria Surveillance Program has previously relied on rapid diagnostic tests and blood smear microscopy with confirmatory polymerase chain reaction (PCR) testing in a subset of cases to further distinguish P. falciparum, P. malariae, P. ovale, and P. vivax species. Here, metagenomic next-generation sequencing identified P. knowlesi mono-infection in six Cambodian patients initially diagnosed with P. malariae by blood smear microscopy in February-May 2020. These findings of recent human infections with P. knowlesi in Cambodia led to the incorporation of P. knowlesi-specific PCR diagnostics to national malaria surveillance efforts.

Indexed as

MalariaMalaria, FalciparumPlasmodium knowlesiAsian PeopleHumansMicroscopyPolymerase Chain Reaction

Identifiers

PMID35895370
PMCPMC9294667
OpenAlexW4285084880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.