Evidence map›Paper›PMID 35895361›Full record

ArticleThe American journal of tropical medicine and hygiene2022

Outbreak of Typhoid Fever in Children of Urban Vellore: A Report from the Surveillance for Enteric Fever in India Cohort.

Manikandan Srinivasan, Kulandaipalayam Natarajan Sindhu, J Senthil Kumar, Ranjith Kumar Ramasamy, Agila Kumari Pragasam, Pratheepa Aasaithampi, Venkata Raghava Mohan, Gagandeep Kang, Jacob John

Open access · hybridAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Risk Factors for Typhoid Fever: Systematic Review.JMIR public health and surveillance · 2025
    Pooled it
  2. Article
  3. Article
  4. Environmental health insights · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Prevalence of UndiagnosedPathogens (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Manikandan SrinivasanWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India.
Kulandaipalayam Natarajan SindhuWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India.
J Senthil KumarWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India.
Ranjith Kumar RamasamyWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India.
Agila Kumari PragasamDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamilnadu, India.
Pratheepa AasaithampiWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India.
Venkata Raghava MohanDepartment of Community Health, Christian Medical College, Vellore, Tamilnadu, India.
Gagandeep KangWellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India.
Jacob JohnDepartment of Community Health, Christian Medical College, Vellore, Tamilnadu, India.
Christian Medical College & Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an outbreak of typhoid fever between April and June 2019 in the Surveillance for Enteric Fever in India cohort, a pediatric cohort from four contiguous semi-urban settlements of Vellore in South India. This cohort of children 6 months to 15 years of age was under surveillance from October 2017 to December 2019. A clustering of typhoid cases in the cohort was noted with reference to time, place, and person. The overall typhoid attack rate in the cohort was 0.9%, with the highest attack rate of 1.7% being documented in one of the four areas. The rate of hospitalization and complications in children who were typhoid positive during the outbreak was 28% and 2%, respectively. Given the background of suboptimal water, sanitation, and hygiene, and the risk of typhoid fever outbreaks in these settings, it is imperative that a typhoid vaccine be considered for introduction as a pragmatic preventive approach.

Indexed as

Typhoid FeverTyphoid-Paratyphoid VaccinesChildCohort StudiesDisease OutbreaksHumansIndiaSanitationTyphoid-Paratyphoid Vaccines

Identifiers

PMID35895361
PMCPMC9294687
OpenAlexW4285086090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.