ArticleAging clinical and experimental research2022
Networks of inflammation, depression, and cognition in aging males and females.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of Environment on the Cognition of Older Adults: A Narrative Review.Brain sciences · 2026Review
- The interplay of life satisfaction and cognitive reserve: implications for cognitive changes in old age.BMC geriatrics · 2026Article
- Statistical evidence in psychological networks.Nature human behaviour · 2026Article
- The cellular choreography of brain aging: a neuroimmune network perspective.Frontiers in aging neuroscience · 2026Review
- Preoperative depressive symptoms as a marker of postoperative delirium risk in older adults: a prospective cohort study in spine surgery.Frontiers in medicine · 2026Article
- Reframing brain aging: neuroinflammation as an interconnected network process.Frontiers in aging · 2026Review
- Evaluating short-term air pollution-related mental health resilience using a directional network.BMC public health · 2025Article
- Bridge symptoms of insomnia, obsessive-compulsive symptoms, and depression/anxiety: a network analysis.BMC psychiatry · 2025Article
- Sex-Specific Inflammatory Profiles Affect Neuropsychiatric Issues in COVID-19 Survivors.Biomolecules · 2025Article
- Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study.Frontiers in psychiatry · 2025Article
- Gender differences in the mental symptom network of high school students in Shanghai, China: a network analysis.BMC public health · 2024Article
- Examining the validity of the Mini-Mental State Examination (MMSE) and its domains using network analysis.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024Article
- Sex differences in childhood maltreatment, inflammation, and adulthood depression: A network analysis.Brain, behavior, & immunity - health · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundPrioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.
aimsTo explore the interactive network of inflammation, depression and cognition by sex in older people.
methodsWe used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70-90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up.
resultsThe networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers.
conclusionsThese findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging.
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