Evidence map›Paper›PMID 35895253›Full record

ArticleApplied biochemistry and biotechnology2023

Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model.

Ragaa H M Salama, Safaa S Ali, Tarek Hamdy M Salama, Mohamed Abu Almged, Tasneem A Alsanory, Aya A Alsanory, Hesham Aboutaleb, Ghada M Ezzat

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In one paragraph

Article in Applied biochemistry and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ragaa H M SalamaFaculty of Medicine, Department of Medical Biochemistry and Molecular Biology, Assiut University, Assiut, 71515, Egypt. r.salama@aun.edu.eg.
Safaa S AliFaculty of Medicine, Department of Histology, Assiut University, Assiut, Egypt.
Tarek Hamdy M SalamaAgriculture Research Institute, Assiut, Egypt.
Mohamed Abu AlmgedAgriculture Research Institute, Assiut, Egypt.
Tasneem A AlsanoryFaculty of Pharmacy, Department of Biochemistry, Assiut University, Assiut, Egypt.
Aya A AlsanoryDepartment of Radiotherapy and Nuclear Medicine, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Hesham AboutalebFaculty of Medicine, Department of Obstetrics and Gynecology, Assiut University Hospital, Assiut, Egypt.
Ghada M EzzatFaculty of Medicine, Department of Medical Biochemistry and Molecular Biology, Assiut University, Assiut, 71515, Egypt. ghadaezzat@aun.edu.eg.ORCID http://orcid.org/0000-0001-8328-6339
Assiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal osteoporosis is a critical issue for female health worldwide. This current study was designed to evaluate the role of nanopowder eggshell (NPES) in healthy and ovariectomy-induced osteoporosis rats. Fifty-six female rats were divided into healthy rats (35) and ovariectomized rats (21). The healthy rats were subdivided into five groups (G1-G5) and received one of the following treatments: saline, 20 or 40 mg/kg of calcium carbonate, and 20 or 40 mg/kg of NPES. The 21 ovariectomized rats were divided into three groups (G6-G8) and received either saline, 40 mg/kg of calcium carbonate, or 40 mg/kg of NPES. Biochemical and histopathological assessments of bone formation and resorption were performed. Biomarkers of bone formation (calcium and osteocalcin (OCN)) and calcium content in left femur ashes were significantly higher in healthy rats given 40-mg/kg NPES than in healthy control rats and healthy rats given 40-mg/kg calcium carbonate. The ovariectomized groups had significantly lower levels of vitamin D3, OCN, and osteoprotegerin (OPG) than the healthy control. Alanine transaminase (ALT), alkaline phosphatase (ALP), and receptor activator of nuclear factor-κB ligand (RANKL) were significantly increased in the ovariectomized group than in the healthy control group. Treatment with NPES and calcium carbonate reduced liver enzymes in ovariectomized rats. NPES treatment significantly increased Vit D3, OCN, OPG, and bone ash mineral content (calcium, magnesium, zinc, and phosphorus) in ovariectomized rats. NPES also increased femur cortical thickness, osteoblast number, and collagen fiber. The current study suggests that NPES can modulate bone turnover biomarkers and increase bone trace elements. Moreover, NPES alleviates bone resorption in ovariectomy-induced osteoporosis.

Indexed as

Bone ResorptionOsteoporosisAnimalsBiomarkersCalciumCalcium CarbonateEgg ShellFemaleHumansOvariectomyRatsRats, Sprague-DawleyBiomarkersCalciumCalcium CarbonateCollagen fiberOsteocalcinOsteoporosisOsteoprotegerinReceptor activator of nuclear factor-κB ligandReused eggshells

Identifiers

PMID35895253
OpenAlexW4288176180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.