Evidence map›Paper›PMID 35895213›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2022

Electrochemical microwell sensor with Fe-N co-doped carbon catalyst to monitor nitric oxide release from endothelial cell spheroids.

Kaoru Hiramoto, Kazuyuki Iwase, Yoshinobu Utagawa, Yuji Nashimoto, Itaru Honma, Kosuke Ino, Hitoshi Shiku

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Recent advances in electrochemiluminescence sensing for in vitro cell analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Review
  2. Enhancing the sensitivity of immunoassays toward single-cell secretion analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
    Article
  3. Article
  4. Recent development of electrochemical devices in analytical chemistry.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kaoru Hiramoto *Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, 980-0845, Japan.
Kazuyuki Iwase *Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, 980-8577, Japan. kazuyuki.iwase.a6@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-5196-741X
Yoshinobu UtagawaGraduate School of Environmental Studies, Tohoku University, Sendai, 980-8579, Japan.
Yuji NashimotoInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, 101-0062, Japan.
Itaru HonmaInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, 980-8577, Japan.
Kosuke InoGraduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan. kosuke.ino@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-4750-4025
Hitoshi ShikuGraduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan. hitoshi.shiku.c3@tohoku.ac.jp.ORCID http://orcid.org/0000-0003-1989-9725
Tohoku University · JPTokyo Medical and Dental University · JP

Funding

Japan Society for Aeronautical and Space Sciences 18H01840Japan Society for the Promotion of Science 18H01999Japan Society for the Promotion of Science 20J21401Japan Society for the Promotion of Science 21H01957Japan Society for the Promotion of Science 21H03803JST COI JPMJCE1303KAKENHI programs 20K15374
6 · The paper itself

Abstract

Endothelial cells have been widely used for vascular biology studies; recent progress in tissue engineering have offered three-dimensional (3D) culture systems for vascular endothelial cells which can be considered as physiologically relevant models. To facilitate the studies, we developed an electrochemical device to detect nitric oxide (NO), a key molecule in the vasculature, for the evaluation of 3D cultured endothelial cells. Using an NO-sensitive catalyst composed of Fe-N co-doped reduced graphene oxide, the real-time monitoring of NO release from the endothelial cell spheroids was demonstrated.

Indexed as

Endothelial CellsNitric OxideCarbonCatalysisTissue EngineeringCarbonNitric OxideComposite carbon materialsElectrocatalystsEndothelial cellsNitric Oxide (NO)Spheroids

Identifiers

PMID35895213
OpenAlexW4288175824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.