Evidence map›Paper›PMID 35895177›Full record

ArticleEJNMMI research2022

[

Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Systematic review ofFrontiers in aging neuroscience · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. PET Imaging with [Antioxidants (Basel, Switzerland) · 2024
    Article
  8. Positron Emission Tomography with [International journal of molecular sciences · 2024
    Article
  9. Correction: [EJNMMI research · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chia-Ju HsiehDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Catherine HouDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Yi ZhuDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Ji Youn LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Neha KohliDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Evan GallagherDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kuiying XuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hsiaoju LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Shihong LiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Meagan J McManusDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. mcmanusm@email.chop.edu.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. rmach@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-7645-2869
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

Superoxide-sensitive radiotracer as a predictive biomarker of Parkinson's disease progressionR01NS114656 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI MCMANUS, MEAGAN JOY · 2020 to 2024
$2.6M
Imaging oxidative stress in an animal model of AD with PETR21AG055142 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MACH, ROBERT H · 2018 to 2019
$443k
NIA NIH HHS AG055142NIA NIH HHS R21 AG055142NINDS NIH HHS R01 NS114656
6 · The paper itself

Abstract

backgroundOxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer's disease (AD). However, tracking oxidative stress in the brain has proven difficult and impeded its use as a biomarker. Herein, we investigate the utility of a novel positron emission tomography (PET) tracer, [

results[

conclusions[

Indexed as

Alzheimer’s diseaseNeurodegenerationNeuroinflammationOxidative stressPositron emission tomographyROStrace

Identifiers

PMID35895177
PMCPMC9329498
OpenAlexW4288174604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.