Evidence map›Paper›PMID 35894699›Full record

ArticleG3 (Bethesda, Md.)2022

Characterization of the cluster MabR prophages of Mycobacterium abscessus and Mycobacterium chelonae.

Jacob Cote, Colin Welch, Madeline Kimble, Dakota Archambault, John Curtis Ross, Hector Orellana, Katelyn Amero, Claire Bourett, Andre Daigle, Keith W Hutchison and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jacob CoteDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0002-4840-7489
Colin WelchDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0002-3876-5418
Madeline KimbleDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0002-0050-5880
Dakota ArchambaultDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0002-2088-9324
John Curtis RossDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
Hector OrellanaDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0002-5994-3797
Katelyn AmeroDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0001-7108-5812
Claire BourettDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0003-2983-022X
Andre DaigleDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0003-2348-3132
Keith W HutchisonDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0003-1171-3164
Sally D MolloyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0002-0478-1209
University of Maine · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
NIGMS NIH HHS P20 GM103423
6 · The paper itself

Abstract

Mycobacterium abscessus is an emerging pathogen of concern in cystic fibrosis and immunocompromised patients and is considered one of the most drug-resistant mycobacteria. The majority of clinical Mycobacterium abscessus isolates carry 1 or more prophages that are hypothesized to contribute to virulence and bacterial fitness. The prophage McProf was identified in the genome of the Bergey strain of Mycobacterium chelonae and is distinct from previously described prophages of Mycobacterium abscessus. The McProf genome increases intrinsic antibiotic resistance of Mycobacterium chelonae and drives expression of the intrinsic antibiotic resistance gene, whiB7, when superinfected by a second phage. The prevalence of McProf-like genomes was determined in sequenced mycobacterial genomes. Related prophage genomes were identified in the genomes of 25 clinical isolates of Mycobacterium abscessus and assigned to the novel cluster, MabR. They share less than 10% gene content with previously described prophages; however, they share features typical of prophages, including polymorphic toxin-immunity systems.

Indexed as

MycobacteriumMycobacterium abscessusMycobacterium chelonaeAnti-Bacterial AgentsHumansProphagesAnti-Bacterial AgentsbacteriophagegenomeMycobacteriumprophage

Identifiers

PMID35894699
PMCPMC9434293
OpenAlexW4288067298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.