Evidence map›Paper›PMID 35894604›Full record

ArticleJournal of virology2022

Host Range Expansion of

Sundharraman Subramanian, John A Dover, Kristin N Parent, Sarah M Doore

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. TheJournal of virology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Two novel phages infectingFrontiers in microbiology · 2025
    Article
  13. Moo19 and B2: Structures ofScience advances · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Viruses · 2024
    Article
  19. Potential of an Isolated Bacteriophage to InactivateAntibiotics (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sundharraman SubramanianDepartment of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
John A DoverDepartment of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Kristin N ParentDepartment of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.ORCID 0000-0002-6095-0628
Sarah M DooreDepartment of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.ORCID 0000-0002-7672-2355
Michigan State University · USUniversity of Florida · US

Funding

Midwest Consortium for High Resolution Cryoelectron MicroscopyU24GM116789 · NIGMS · PURDUE UNIVERSITY · PI BULLITT, ESTHER, DAI, WEI · 2017 to 2021
$3.5M
Bacteriophage interactions with enteric pathogens-the essential role of inner membrane protein YajCR35GM140803 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Kristin N Parent · 2021 to 2026
$2.5M
Sf6 as a model system for understanding the mechanisms of virus: host recognitionR01GM110185 · NIGMS · MICHIGAN STATE UNIVERSITY · PI PARENT, KRISTIN N · 2015 to 2019
$1.4M
NIGMS NIH HHS R01 GM110185NIGMS NIH HHS R35 GM140803NIGMS NIH HHS U24 GM116789
6 · The paper itself

Abstract

The first critical step in a virus's infection cycle is attachment to its host. This interaction is precise enough to ensure the virus will be able to productively infect the cell, but some flexibility can be beneficial to enable coevolution and host range switching or expansion. Bacteriophage Sf6 utilizes a two-step process to recognize and attach to its host Shigella flexneri. Sf6 first recognizes the lipopolysaccharide (LPS) of S. flexneri and then binds outer membrane protein (Omp) A or OmpC. This phage infects serotype Y strains but can also form small, turbid plaques on serotype 2a

Indexed as

Point MutationBacteriophagesGlycoside HydrolasesHost SpecificityLipopolysaccharide ReceptorsLipopolysaccharidesO AntigensShigella flexneriViral Tail ProteinsGlycoside HydrolasesLipopolysaccharide ReceptorsLipopolysaccharidesO Antigenstailspike protein, bacteriophageViral Tail Proteinsbacteriophage evolutionbacteriophagesexperimental evolutionprotein structure-functionstructural biologyvirus-host interactions

Identifiers

PMID35894604
PMCPMC9400499
OpenAlexW4288066944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.