Evidence map›Paper›PMID 35894525›Full record

ArticleThe journal of international advanced otology2022

The Spatiotemporal Expression of Ring1B in the Postnatal Mouse Cochlea.

Linhui Li, Yuanping Xiong, Bin Chen, Yazhi Xing

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In one paragraph

Article in The journal of international advanced otology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Linhui LiDepartment of Otolaryngology, Shanghai University of Medicine and Health Sciences, Shanghai Jiading Central Hospital, Shanghai, China.
Yuanping XiongDepartment of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
Bin ChenDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Sixth People's Hospital, Shanghai, China; Otolaryngology Institute of Shanghai, Jiao Tong University, Shanghai, China/Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
Yazhi XingDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Sixth People's Hospital, Shanghai, China; Otolaryngology Institute of Shanghai, Jiao Tong University, Shanghai, China/Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
Shanghai Sixth People's Hospital · CNJiading District Central Hospital · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpigenetic regulation plays significant role in the development of the inner ear. It is known that Ring1B can monoubiquitinate H2AK119 to compact nucleosomes and block gene transcription. Ring1B plays crucial role in embryonic development, heterochromatin function, stem cell maintenance and so on. However, it is still unknown whether Ring1B plays a role in the development of inner ear.

methodsHere, we used postnatal C56BL/6J mice to examine the expression of Ring1B in the cochlea using real-time quantitative polymerase chain reaction, Western blot, and immunofluorescence staining.

resultsRing1B mRNA expression was observed at postnatal day 0 and postnatal day 14 cochlea. Ring1B protein was expressed in the cochlea on postnatal days 0, 14, and 30. The Ring1B was observed to be expressed in spiral ganglion cells at postnatal days 0, 14, and 30. Additionally, Ring1B was expressed in hair cells at postnatal days 0, 14, and 30.

conclusionOur results provide the basic expression pattern of Ring1B and might be helpful for future investigations of the detailed role of Ring1B in the cochlea.

Indexed as

Ear, InnerEpigenesis, GeneticAnimalsCochleaFemaleHair Cells, AuditoryMicePregnancySpiral Ganglion

Identifiers

PMID35894525
PMCPMC9404321
OpenAlexW4285799080

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