ArticlePolymers2022
Parylene C as an Insulating Polymer for Implantable Neural Interfaces: Acute Electrochemical Impedance Behaviors in Saline and Pig Brain In Vitro.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Electrochemical Evaluation of Polymer-Based Microelectrode Arrays: Analytical Performance on Oxygen and Hydrogen Peroxide.Sensors (Basel, Switzerland) · 2026Article
- Field-Programmable Mobile Magneto-Photonic Metaparticles for Active Light Manipulation and Steering.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Emerging Implantable Sensor Technologies at the Intersection of Engineering and Brain Science.Biosensors · 2025Review
- A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution.Nature communications · 2025Article
- A Water-Resistant, Self-Healing Encapsulation Layer for a Stable, Implantable Wireless Antenna.Polymers · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Parylene is used as encapsulating material for medical devices due to its excellent biocompatibility and insulativity. Its performance as the insulating polymer of implantable neural interfaces has been studied in electrolyte solutions and in vivo. Biological tissue in vitro, as a potential environment for characterization and application, is convenient to access in the fabrication lab of polymer and neural electrodes, but there has been little study investigating the behaviors of Parylene in the tissue in vitro. Here, we investigated the electrochemical impedance behaviors of Parylene C polymer coating both in normal saline and in a chilled pig brain in vitro by performing electrochemical impedance spectroscopy (EIS) measurements of platinum (Pt) wire neural electrodes. The electrochemical impedance at the representative frequencies is discussed, which helps to construct the equivalent circuit model. Statistical analysis of fitted parameters of the equivalent circuit model showed good reliability of Parylene C as an insulating polymer in both electrolyte models. The electrochemical impedance measured in pig brain in vitro shows marked differences from that of saline.
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Registered trials
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