Evidence map›Paper›PMID 35893907›Full record

Trial reportNutrients2022

Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial.

Sophie De Niet, Mickaël Trémège, Monte Coffiner, Anne-Francoise Rousseau, Doriane Calmes, Anne-Noelle Frix, Fanny Gester, Muriel Delvaux, Anne-Francoise Dive, Elora Guglielmi and 6 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 13 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 13 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  14. Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Sophie De NietClinical Department, Laboratoires SMB SA, 1080 Brussels, Belgium.ORCID 0000-0003-4393-2636
Mickaël TrémègeClinical Department, Laboratoires SMB SA, 1080 Brussels, Belgium.
Monte CoffinerClinical Department, Laboratoires SMB SA, 1080 Brussels, Belgium.
Anne-Francoise RousseauDepartment of Intensive Care, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.ORCID 0000-0002-4157-6570
Doriane CalmesDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Anne-Noelle FrixDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Fanny GesterDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Muriel DelvauxDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Anne-Francoise DiveDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Elora GuglielmiDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Monique HenketDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Alicia StaderoliDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Didier MaesenDepartment of Hospital Pharmacy, CHU Sart-Tilman, 4000 Liège, Belgium.
Renaud LouisDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.
Julien GuiotDepartment of Pneumology and Allergology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium.ORCID 0000-0001-7800-1730
Etienne CavalierDepartment of Clinical Chemistry, University of Liège, CIRM, CHU Sart-Tilman, 4000 Liège, Belgium.ORCID 0000-0003-0947-2226
University of Liège · BESMB (Belgium) · BECentre Hospitalier Universitaire de Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo. The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (4 days vs. 8 days;

Indexed as

COVID-19CholecalciferolDietary SupplementsDouble-Blind MethodHospitalizationHumansPilot ProjectsRetrospective StudiesSARS-CoV-2Vitamin DVitaminsCholecalciferolVitamin DVitaminscalcifediolcholecalciferolCOVID-19hospitalizationSARS-CoV-2vitamin D

Identifiers

PMID35893907
PMCPMC9330587
OpenAlexW4287877511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.