ArticleNutrients2022
Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest-Activity Rhythm in Shift Workers.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Association Between Sleep Quality and Geriatric Hip Fracture: A Prospective Comparative Study.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Transcranial near infrared therapy reprograms metabolism to rescue sleep and place cell functionality.iScience · 2025Article
- The Mechanisms of Magnesium in Sleep Disorders.Nature and science of sleep · 2025Review
- The role of vitamin D in sleep regulation: mechanisms, clinical advances, and future directions.Frontiers in nutrition · 2025Review
- From Garden to Pillow: Understanding the Relationship between Plant-Based Nutrition and Quality of Sleep.Nutrients · 2024Review
- Circadian Rhythms Characteristics of Nurses Providing Direct Patient Care: An Observational Study.Safety and health at work · 2024Article
- Serum Calcium and Magnesium Levels, Not 25-Hydroxyvitamin D, Are Associated With Sleep Quality in Airline Pilots.Cureus · 2023Article
- The association between nutritional status and sleep quality of Chinese community-dwelling older adults.Aging clinical and experimental research · 2023Article
- Sleep disorder, Mediterranean diet, and all-cause and cause-specific mortality: a prospective cohort study.BMC public health · 2023Article
- Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance.International journal of environmental research and public health · 2023Article
- Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies.Nutrients · 2023Review
- Effect of circadian clock and claudin regulations on inulin-induced calcium absorption in the mouse intestinal tract.Bioscience of microbiota, food and health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Vitamin D deficiency is prevalent in many developed countries, and several studies suggest that vitamin D plays an essential role in brain function. A recent study showed that vitamin D deficiency was closely associated with daytime sleepiness and shorter sleep time. The relationshipbetween vitamin D levels and calcium levels is well established, and calcium level regulates slow-wave sleep generation. It is conceivable that the sleep disturbance in vitamin D deficiency may be due to an altered calcium level. Nonetheless, calcium levels, sleep disturbances, and activity rhythms have not been investigated directly. Therefore, we hypothesized that calcium and vitamin D levels might be important in regulating sleep and activity rhythm, and we analyzed the correlation with calcium levels by actigraphy analysis. Interestingly, a negative correlation was found between calcium level and sleep latency, total sleep time, use of sleep medicine, and daytime dysfunction among shift workers. In contrast, non-shift workers showed a negative correlation between the calcium level and the circadian phase. These findings suggest that low serum calcium levels may disrupt sleep-wake control and rest-activity rhythm, even if they are within the normal range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.