Evidence map›Paper›PMID 35893826›Full record

ArticleVaccines2022

DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model.

Mirco Compagnone, Eleonora Pinto, Erika Salvatori, Lucia Lione, Antonella Conforti, Silvia Marchese, Micol Ravà, Kathryn Ryan, Yper Hall, Emma Rayner and 6 more

Abstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Ferrets: A powerful model of SARS-CoV-2.Zoological research · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mirco CompagnoneNeomatrix, 00128 Rome, Italy.
Eleonora PintoTakis, 00128 Rome, Italy.ORCID 0000-0003-4955-5528
Erika SalvatoriTakis, 00128 Rome, Italy.ORCID 0000-0001-9875-4465
Lucia LioneTakis, 00128 Rome, Italy.ORCID 0000-0001-8927-1832
Antonella ConfortiEvvivax, 00128 Rome, Italy.ORCID 0000-0001-8524-5936
Silvia MarcheseINGM-Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi", 20122 Milan, Italy.ORCID 0000-0003-3822-7174
Micol RavàDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Kathryn RyanUK Health Security Agency (UKHSA), Porton Down, Salisbury SP4 0JG, UK.
Yper HallUK Health Security Agency (UKHSA), Porton Down, Salisbury SP4 0JG, UK.ORCID 0000-0002-8537-8920
Emma RaynerUK Health Security Agency (UKHSA), Porton Down, Salisbury SP4 0JG, UK.
Francisco J SalgueroUK Health Security Agency (UKHSA), Porton Down, Salisbury SP4 0JG, UK.ORCID 0000-0002-5315-3882
Jemma PatersonUK Health Security Agency (UKHSA), Porton Down, Salisbury SP4 0JG, UK.ORCID 0000-0002-1613-6397
Matteo IannaconeDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-9370-2671
Raffaele De FrancescoINGM-Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi", 20122 Milan, Italy.ORCID 0000-0001-8754-5123
Luigi AurisicchioNeomatrix, 00128 Rome, Italy.ORCID 0000-0003-3110-4534
Fabio PalomboNeomatrix, 00128 Rome, Italy.ORCID 0000-0003-0473-4901

Funding

TRANSVAC2 TRANSVAC2 Infrastructure Call 2002-08-Covivax
6 · The paper itself

Abstract

The COVID-19 pandemic is entering a new era with the approval of many SARS-CoV-2 vaccines. In spite of the restoration of an almost normal way of life thanks to the immune protection elicited by these innovative vaccines, we are still facing high viral circulation, with a significant number of deaths. To further explore alternative vaccination platforms, we developed COVID-

Indexed as

DNA vaccinesferretsimmune responsesSARS-CoV-2

Identifiers

PMID35893826
PMCPMC9332309

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.