Evidence map›Paper›PMID 35893724›Full record

ArticlePharmacy (Basel, Switzerland)2022

A Guide to a Pharmacist-Led Pharmacogenetic Testing and Counselling Service in an Interprofessional Healthcare Setting.

Céline K Stäuble, Chiara Jeiziner, Anna Bollinger, Florine M Wiss, Martin Hatzinger, Kurt E Hersberger, Thomas Ihde, Markus L Lampert, Thorsten Mikoteit, Henriette E Meyer Zu Schwabedissen and 1 more

Abstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Céline K StäublePharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0002-2437-4803
Chiara JeizinerPharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0002-1132-0240
Anna BollingerPharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.
Florine M WissPharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.
Martin HatzingerPsychiatric Services Solothurn, Solothurner Spitäler AG, Faculty of Medicine, University of Basel, 4503 Solothurn, Switzerland.
Kurt E HersbergerPharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0001-8678-697X
Thomas IhdeInstitute of Psychiatry, Spitäler Frutigen Meiringen Interlaken AG (fmiAG), 3800 Unterseen, Switzerland.
Markus L LampertPharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0001-7037-2799
Thorsten MikoteitPsychiatric Services Solothurn, Solothurner Spitäler AG, Faculty of Medicine, University of Basel, 4503 Solothurn, Switzerland.ORCID 0000-0003-2166-6330
Henriette E Meyer Zu SchwabedissenBiopharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0003-0458-4579
Samuel S AllemannPharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0003-4067-9401

Funding

Stiftung zur Förderung des pharmazeutischen Nachwuchses in Basel n.a.
6 · The paper itself

Abstract

Genetic predisposition is one factor influencing interindividual drug response. Pharmacogenetic information can be used to guide the selection and dosing of certain drugs. However, the implementation of pharmacogenetics (PGx) in clinical practice remains challenging. Defining a formal structure, as well as concrete procedures and clearly defined responsibilities, may facilitate and increase the use of PGx in clinical practice. Over 140 patient cases from an observational study in Switzerland formed the basis for the design and refinement of a pharmacist-led pharmacogenetics testing and counselling service (PGx service) in an interprofessional setting. Herein, we defined a six-step approach, including: (1) patient referral; (2) pre-test-counselling; (3) PGx testing; (4) medication review; (5) counselling; (6) follow-up. The six-step approach supports the importance of an interprofessional collaboration and the role of pharmacists in PGx testing and counselling across healthcare settings.

Indexed as

clinical pharmacycommunity pharmacyhospital pharmacymedication reviewpersonalized medicinepharmaceutical carepharmacogenomicspharmacy serviceprimary caresecondary care

Identifiers

PMID35893724
PMCPMC9326676

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.