Evidence map›Paper›PMID 35893619›Full record

ArticlePlants (Basel, Switzerland)2022

Bio-Guided Isolation of SARS-CoV-2 Main Protease Inhibitors from Medicinal Plants: In Vitro Assay and Molecular Dynamics.

Hossam M Abdallah, Ali M El-Halawany, Khaled M Darwish, Mardi M Algandaby, Gamal A Mohamed, Sabrin R M Ibrahim, Abdulrahman E Koshak, Sameh S Elhady, Sana A Fadil, Ali A Alqarni and 2 more

Open access · goldAbstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Identification of potential SARS-CoV-2 MJournal of computer-aided molecular design · 2026
    Article
  2. Article
  3. Review
  4. Assessing the antibacterial potential of 6-gingerol: Combined experimental and computational approaches.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  5. Potential Therapeutic Target and Vaccines for SARS-CoV-2.Pathogens (Basel, Switzerland) · 2023
    Article
  6. Review
  7. Article
  8. The effect ofFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Hossam M AbdallahDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-0234-7492
Ali M El-HalawanyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.ORCID 0000-0002-5864-1674
Khaled M DarwishDepartment of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0002-0597-482X
Mardi M AlgandabyDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Gamal A MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-2971-6008
Sabrin R M IbrahimPreparatory Year Program, Department of Chemistry, Batterjee Medical College, Jeddah 21442, Saudi Arabia.ORCID 0000-0002-6858-7560
Abdulrahman E KoshakDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-0179-9793
Sameh S ElhadyDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-3799-0581
Sana A FadilDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-4986-1904
Ali A AlqarniDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ashraf B Abdel-NaimDepartment of Pharmacology and Toxicology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mahmoud A ElfakyDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
King Abdulaziz University · SABatterjee Medical CollegeCairo University · EGSuez Canal University · EG

Funding

Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, RG-4-130-42
6 · The paper itself

Abstract

Since the emergence of the pandemic of the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the discovery of antiviral phytoconstituents from medicinal plants against SARS-CoV-2 has been comprehensively researched. In this study, thirty-three plants belonging to seventeen different families used traditionally in Saudi Arabia were tested in vitro for their ability to inhibit the SARS-CoV-2 main protease (M

Indexed as

6-gingerol6-paradolcoronavirusgardenin ASARS-CoV-2 Egyptian strainSARS-CoV-2 main proteasethymoquinone

Identifiers

PMID35893619
PMCPMC9332707
OpenAlexW4287148258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.