ReviewMicroorganisms2022
The Role of Rumen Microbiota and Its Metabolites in Subacute Ruminal Acidosis (SARA)-Induced Inflammatory Diseases of Ruminants.
Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 81 citations in OpenAlex.
- Abomasal Disorders in Dairy Cows During the Transition Period: Interconnected Risk Factors and Repercussions on Health and Culling Rate.Animals : an open access journal from MDPI · 2026Review
- Microbial and Metabolic Dysbiosis in Ruminal Acidosis: Mechanisms, Host Responses, and Microbiota-Targeted Mitigation Strategies.Microorganisms · 2026Review
- Balancing High Yield and Metabolic Health in Dairy Ruminants: The Central Hub Role of the Rumen Microbiota.Veterinary sciences · 2026Review
- Rumen-Protected Taurine Alleviates Heat Stress Injury in Hu Sheep by Regulating Inflammatory Response, Gut Microbiota and Transcriptome.Animals : an open access journal from MDPI · 2026Article
- Multi-omics analysis reveals circadian disruption of rumen microbiota and serum metabolites in Tibetan sheep under transport stress.BMC microbiology · 2026Article
- Curcumin modulates hepatic pyroptosis-autophagy crosstalk induced by aflatoxin B1 via rumen microbiota-blood-liver axis.Microbiome · 2026Article
- Integrating Diagnostic Tools for Early Recognition of Rumenitis in a Neonatal Calf.Animals : an open access journal from MDPI · 2026Article
- Responsive changes of rumen metabolome and fatty acid profiles in blood and milk in dairy cows with different sorting behavior.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- The impact of rumen and hindgut microbiomes on the persistent productivity of long-lived dairy cows.Microbiome · 2026Article
- Dynamic Changes in Gut Microbiota Composition and Function over Time in Suckling Raccoon Dogs.Animals : an open access journal from MDPI · 2026Article
- Editorial: Threats and strategies of nutritional metabolic disorders and poisoning diseases in ruminants.Frontiers in veterinary science · 2026Article
- Comprehensive improvement of induced ruminal acidosis in lambs: targeted microencapsulated essential oils and marine algae restore rumen function, systemic health, immunity, and welfare.Frontiers in veterinary science · 2026Article
- Metabolic and metataxonomic changes in lactating holstein dairy cows during the transition from heat stress to the recovery period.Journal of animal science and technology · 2026Article
- Microbiota-derived indole-3-acetic acid alleviates rumen epithelial barrier dysfunction during the peripartum period through AhR signaling.NPJ biofilms and microbiomes · 2025Article
- Ruminal microbial dysbiosis induces mastitis in dairy goats by activating oxidative stress and ferritinophagy-ferroptosis.iScience · 2025Article
- Rumen Fluid Metabolomics and Microbiome Profiling of Dairy Cows Fed Combinations of Prebiotics, Essential Oil Blend, and Onion Peel Using the RUSITEC System.Metabolites · 2025Article
- Targeting the Gut-Mammary Axis for Understanding Mastitis Pathogenesis and Therapeutic Strategies.Veterinary sciences · 2025Review
- Synergistic effects ofVeterinary world · 2025Article
- Ruminal dysbiosis-induced mastitis: new insight into the pathogenesis of mastitis.Journal of animal science and biotechnology · 2025Review
- Multi-omics insights into microbiome-rumen epithelium interaction mechanisms underlying subacute rumen acidosis tolerance in dairy goats.Genome biology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Subacute ruminal acidosis (SARA) is a common metabolic disease in ruminants. In the early stage of SARA, ruminants do not exhibit obvious clinical symptoms. However, SARA often leads to local inflammatory diseases such as laminitis, mastitis, endometritis and hepatitis. The mechanism by which SARA leads to inflammatory diseases is largely unknown. The gut microbiota is the totality of bacteria, viruses and fungi inhabiting the gastrointestinal tract. Studies have found that the gut microbiota is not only crucial to gastrointestinal health but also involved in a variety of disease processes, including metabolic diseases, autoimmune diseases, tumors and inflammatory diseases. Studies have shown that intestinal bacteria and their metabolites can migrate to extraintestinal distal organs, such as the lung, liver and brain, through endogenous pathways, leading to related diseases. Combined with the literature, we believe that the dysbiosis of the rumen microbiota, the destruction of the rumen barrier and the dysbiosis of liver function in the pathogenesis of SARA lead to the entry of rumen bacteria and/or metabolites into the body through blood or lymphatic circulation and place the body in the "chronic low-grade" inflammatory state. Meanwhile, rumen bacteria and/or their metabolites can also migrate to the mammary gland, uterus and other organs, leading to the occurrence of related inflammatory diseases. The aim of this review is to describe the mechanism by which SARA causes inflammatory diseases to obtain a more comprehensive and profound understanding of SARA and its related inflammatory diseases. Meanwhile, it is also of great significance for the joint prevention and control of diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.