Evidence map›Paper›PMID 35893552›Full record

ArticleMicroorganisms2022

LC-MS/MS-Based Fungicide Accumulation Assay to Demonstrate Efflux Activity in the Wheat Pathogen

Guillaume Fouché, Dominique Rosati, Catherine Venet, Hervé Josserand, Marie-Pascale Latorse, Danièle Debieu, Sabine Fillinger

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guillaume FouchéUR BIOGER, INRAE, Université Paris-Saclay, 78850 Thiverval-Grignon, France.
Dominique RosatiLa Dargoire Research Center, Bayer SAS, 69009 Lyon, France.
Catherine VenetLa Dargoire Research Center, Bayer SAS, 69009 Lyon, France.
Hervé JosserandLa Dargoire Research Center, Bayer SAS, 69009 Lyon, France.
Marie-Pascale LatorseLa Dargoire Research Center, Bayer SAS, 69009 Lyon, France.
Danièle DebieuUR BIOGER, INRAE, Université Paris-Saclay, 78850 Thiverval-Grignon, France.
Sabine FillingerUR BIOGER, INRAE, Université Paris-Saclay, 78850 Thiverval-Grignon, France.ORCID 0000-0003-4683-0803
Bayer (France) · FRUniversité Paris-Saclay · FR

Funding

Bayer (France) R&D contract 16H0090RD
6 · The paper itself

Abstract

Increased drug efflux compromises the efficacy of a large panel of treatments in the clinic against cancer or bacterial, fungal, and viral diseases, and in agriculture due to the emergence of multidrug-resistant pathogenic fungi. Until recently, to demonstrate increased drug efflux, the use of labeled drugs or fluorescent dyes was necessary. With the increasing sensitivity of detection devices, direct assessment of drug efflux has become realistic. Here, we describe a medium-throughput method to assess the intracellular drug concentration in the plant pathogenic fungus

Indexed as

intracellular drug accumulationmedium-throughput assaymultidrug resistancenon-radioactive assay

Identifiers

PMID35893552
PMCPMC9331226
OpenAlexW4287832688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.