Evidence map›Paper›PMID 35893345›Full record

ArticleJournal of clinical medicine2022

Prioritisation of Adverse Drug Events Leading to Hospital Admission and Occurring during Hospitalisation: A RAND Survey.

Annette Haerdtlein, Anna Maria Boehmer, Katharina Karsten Dafonte, Marietta Rottenkolber, Ulrich Jaehde, Tobias Dreischulte

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Annette HaerdtleinInstitute of General Practice and Family Medicine, University Hospital, LMU Munich, 80336 Munich, Germany.
Anna Maria BoehmerDepartment of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, 53121 Bonn, Germany.
Katharina Karsten DafonteInstitute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127 Bonn, Germany.
Marietta RottenkolberInstitute of General Practice and Family Medicine, University Hospital, LMU Munich, 80336 Munich, Germany.
Ulrich JaehdeDepartment of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, 53121 Bonn, Germany.
Tobias DreischulteInstitute of General Practice and Family Medicine, University Hospital, LMU Munich, 80336 Munich, Germany.

Funding

Federal Ministry of Education and Research 01ZZ1910*
6 · The paper itself

Abstract

(1) Adverse drug events (ADEs) are a common cause of emergency department visits and occur frequently during hospitalisation. Instruments that facilitate the detection of the most relevant ADEs could lead to a more targeted and efficient use of limited resources in research and practice. (2) We conducted two consensus processes based on the RAND/UCLA appropriateness method, in order to prioritise ADEs leading to hospital admission (panel 1) and occurring during hospital stay (panel 2) for inclusion in future ADE measurement instruments. In each panel, the experts were asked to assess the "overall importance" of each ADE on a four-point Likert scale (1 = not important to 4 = very important). ADEs with a median rating of ≥3 without disagreement were defined as "prioritised". (3) The 13 experts in panel 1 prioritised 38 out of 65 ADEs, while the 12 experts in panel 2 prioritised 34 out of 63 ADEs. The highest rated events were acute kidney injury and hypoglycaemia (both panels), as well as Stevens-Johnson syndrome in panel 1 and rhabdomyolysis in panel 2. (4) The survey led to a set of ADEs for which there was consensus that they were of particular importance as presentations of acute medication-related harm, thereby providing a focus for further medication safety research and clinical practice.

Indexed as

adverse drug eventsconsensusdrug-related side effectsmedication safetyprioritisationRAND survey

Identifiers

PMID35893345
PMCPMC9332872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.