Evidence map›Paper›PMID 35893250›Full record

ArticleMetabolites2022

MAVEN2: An Updated Open-Source Mass Spectrometry Exploration Platform.

Phillip Seitzer, Bryson Bennett, Eugene Melamud

Abstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  15. Human cytomegalovirus promotesJournal of virology · 2025
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  20. Human cytomegalovirus promotesbioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Phillip SeitzerCalico Life Sciences, LLC, South San Francisco, CA 94080, USA.ORCID 0000-0002-7379-8960
Bryson BennettCalico Life Sciences, LLC, South San Francisco, CA 94080, USA.
Eugene MelamudCalico Life Sciences, LLC, South San Francisco, CA 94080, USA.ORCID 0000-0002-5943-6189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAVEN, an open-source software program for analysis of LC-MS metabolomics data, was originally released in 2010. As mass spectrometry has advanced in the intervening years, MAVEN has been periodically updated to reflect this advancement. This manuscript describes a major update to the program, MAVEN2, which supports LC-MS/MS analysis of metabolomics and lipidomics samples. We have developed algorithms to support MS/MS spectral matching and efficient search of large-scale fragmentation libraries. We explore the ability of our approach to separate authentic from spurious metabolite identifications using a set of standards spiked into water and yeast backgrounds. To support our improved lipid identification workflow, we introduce a novel in-silico lipidomics library covering major lipid classes and compare searches using our novel library to searches with existing in-silico lipidomics libraries. MAVEN2 source code and cross-platform application installers are freely available for download from GitHub under a GNU permissive license [ver 3], as are the in silico lipidomics libraries and corresponding code repository.

Indexed as

fragmentationGUIidentificationlipidomicsmetabolomicsopen-sourcesoftwarevisualization

Identifiers

PMID35893250
PMCPMC9330773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.