Evidence map›Paper›PMID 35893244›Full record

ReviewMetabolites2022

NMR and Metabolomics-A Roadmap for the Future.

David S Wishart, Leo L Cheng, Valérie Copié, Arthur S Edison, Hamid R Eghbalnia, Jeffrey C Hoch, Goncalo J Gouveia, Wimal Pathmasiri, Robert Powers, Tracey B Schock and 2 more

Abstract readReview
In one paragraph

Review in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. HarmonizedAnalytical chemistry · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Lifestyles, metabolome and diabetic kidney disease: a cohort study.QJM : monthly journal of the Association of Physicians · 2026
    Article
  12. Article
  13. Article
  14. Characterization of phytoplankton-excreted metabolites mediating carbon flux through the surface ocean.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David S WishartDepartments of Biological Sciences and Computing Science, University of Alberta, Edmonton, AB T6G 2E9, Canada.ORCID 0000-0002-3207-2434
Leo L ChengDepartment of Pathology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Valérie CopiéDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59715, USA.ORCID 0000-0002-2778-1463
Arthur S EdisonComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-5686-2350
Hamid R EghbalniaDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT 06030-3305, USA.
Jeffrey C HochDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT 06030-3305, USA.
Goncalo J GouveiaComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Wimal PathmasiriNutrition Research Institute, Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-5199-5744
Robert PowersDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA.ORCID 0000-0001-9948-6837
Tracey B SchockNational Institute of Standards and Technology (NIST), Chemical Sciences Division, Charleston, SC 29412, USA.ORCID 0000-0002-1808-7816
Lloyd W SumnerInterdisciplinary Plant Group, MU Metabolomics Center, Bond Life Sciences Center, Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-4086-663X
Mario UchimiyaComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
The BMRB as an evolving resource for biomolecular structure-function researchR01GM109046 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HOCH, JEFFREY C · 2014 to 2022
$6.6M
Portal for Open Computational Metabolomics Tools - Yr 4 U2C SupplementU2CES030167 · NIEHS · UNIVERSITY OF GEORGIA · PI EDISON, ARTHUR S · 2018 to 2021
$4.2M
NP-MRD: Natural Products Magnetic Resonance DatabaseU24AT010811 · NCCIH · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI CORT, JOHN R · 2020 to 2024
$4.1M
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuliR01AG070257 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE G, XIE, ZHONGCONG · 2021 to 2025
$3.9M
Metabolic Control of gut-brain axis in Familial dysautonomia Supplement to parent grant 1R01DK117473-01A1 to support a PhD candidate/graduate student from an under-represented minorityR01DK117473 · NIDDK · MONTANA STATE UNIVERSITY - BOZEMAN · PI COPIE, VALERIE, WALK, SETH T · 2018 to 2022
$3.0M
The molecular mechanism linking respiratory NADH oxidation and virulence in Staphylococcus aureusR01AI148160 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GENNIS, ROBERT B · 2020 to 2024
$2.6M
Identification of prostate cancer aggressiveness using hyperpolarized polyamine metabolic ratesR21CA243255 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2019 to 2020
$436k
NCCIH NIH HHS 5U24AT010811-02,NCCIH NIH HHS U24 AT010811NCI NIH HHS R21 CA243255NIAID NIH HHS R01 AI148160NIA NIH HHS R01 AG070257NIDDK NIH HHS R01 DK117473NIEHS NIH HHS U2C ES030167NIGMS NIH HHS P20 GM113126NIGMS NIH HHS P41 GM111135NIGMS NIH HHS R01 GM109046NIH HHS AG070257NIH HHS CA243255NIH HHS P20 GM113126NIH HHS P41GM111135NIH HHS R01AI148160NIH HHS R01AI162321NIH HHS R01DK117473NIH HHS R01GM109046NIH HHS U2CES030167
6 · The paper itself

Abstract

Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes are measured with various analytical platforms including liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). While LC-MS methods are becoming increasingly popular in the field of metabolomics (accounting for more than 70% of published metabolomics studies to date), there are considerable benefits and advantages to NMR-based methods for metabolomic studies. In fact, according to PubMed, more than 926 papers on NMR-based metabolomics were published in 2021-the most ever published in a given year. This suggests that NMR-based metabolomics continues to grow and has plenty to offer to the scientific community. This perspective outlines the growing applications of NMR in metabolomics, highlights several recent advances in NMR technologies for metabolomics, and provides a roadmap for future advancements.

Indexed as

advancesimagingmetabolomicsNMR spectroscopyreview

Identifiers

PMID35893244
PMCPMC9394421

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.