Evidence map›Paper›PMID 35893137›Full record

ArticleJournal of fungi (Basel, Switzerland)2022

Digoxin Derivatives Sensitize a

Daniel Clemente de Moraes, Ana Claudia Tessis, Rodrigo Rollin-Pinheiro, Jefferson Luiz Princival, José Augusto Ferreira Perez Villar, Leandro Augusto Barbosa, Eliana Barreto-Bergter, Antônio Ferreira-Pereira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel Clemente de MoraesDepartamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Avenida Carlos Chagas Filho 373, Rio de Janeiro 21941-590, Brazil.
Ana Claudia TessisInstituto Federal do Rio de Janeiro, Rua Senador Furtado 121, Rio de Janeiro 20270-021, Brazil.
Rodrigo Rollin-PinheiroDepartamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Avenida Carlos Chagas Filho 373, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-8316-4670
Jefferson Luiz PrincivalLaboratory of Cell Biochemistry, Universidade Federal de São João del Rei, Campus Centro-Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho 400, Divinópolis 35501-296, Brazil.
José Augusto Ferreira Perez VillarLaboratory of Cell Biochemistry, Universidade Federal de São João del Rei, Campus Centro-Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho 400, Divinópolis 35501-296, Brazil.ORCID 0000-0003-1580-0644
Leandro Augusto BarbosaLaboratory of Cell Biochemistry, Universidade Federal de São João del Rei, Campus Centro-Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho 400, Divinópolis 35501-296, Brazil.ORCID 0000-0002-4631-0130
Eliana Barreto-BergterDepartamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Avenida Carlos Chagas Filho 373, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-8944-9415
Antônio Ferreira-PereiraDepartamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Avenida Carlos Chagas Filho 373, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-0474-8388
Universidade Federal do Rio de Janeiro · BRFederal University of São João del-Rei · BRInstituto Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The poor outcome of treatments for fungal infections is a consequence of the increasing incidence of resistance to antifungal agents, mainly due to the overexpression of efflux pumps. To surpass this mechanism of resistance, a substance able to inhibit these pumps could be administered in association with antifungals.

Indexed as

digoxinefflux pumpfluconazolePdr5pSaccharomyces cerevisiaeyeast

Identifiers

PMID35893137
PMCPMC9330353
OpenAlexW4287092007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.