Evidence map›Paper›PMID 35893116›Full record

ArticleMedical sciences (Basel, Switzerland)2022

Predictors of Invasiveness in Adenocarcinoma of Lung with Lepidic Growth Pattern.

Timothy J Young, Ramin Salehi-Rad, Reza Ronaghi, Jane Yanagawa, Puja Shahrouki, Bianca E Villegas, Brian Cone, Gregory A Fishbein, William D Wallace, Fereidoun Abtin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical sciences (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Timothy J YoungDivision of Pulmonary and Critical Care, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Ramin Salehi-RadDivision of Pulmonary and Critical Care, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Reza RonaghiDivision of Pulmonary and Critical Care, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Jane YanagawaDepartment of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Puja ShahroukiDepartment of Radiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8554-2794
Bianca E VillegasDepartment of Radiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Brian ConeDepartment of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Gregory A FishbeinDepartment of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-3632-5654
William D WallaceDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Fereidoun AbtinDepartment of Radiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Igor BarjaktarevicDivision of Pulmonary and Critical Care, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8096-0858
University of California, Los Angeles · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung adenocarcinoma with lepidic growth pattern (LPA) is characterized by tumor cell proliferation along intact alveolar walls, and further classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive lepidic predominant adenocarcinoma (iLPA). Accurate diagnosis of lepidic lesions is critical for appropriate prognostication and management as five-year survival in patients with iLPA is lower than in those with AIS and MIA. We aimed to evaluate the accuracy of CT-guided core needle lung biopsy classifying LPA lesions and identify clinical and radiologic predictors of invasive disease in biopsied lesions. Thirty-four cases of adenocarcinoma with non-invasive lepidic growth pattern on core biopsy pathology that subsequently were resected between 2011 and 2018 were identified. Invasive LPA vs. non-invasive LPA (AIS or MIA) was defined based on explant pathology. Histopathology of core biopsy and resected tumor specimens was compared for concordance, and clinical, radiologic and pathologic variables were analyzed to assess for correlation with invasive disease. The majority of explanted tumors (70.6%) revealed invasive disease. Asian race (

Indexed as

AdenocarcinomaAdenocarcinoma in SituAdenocarcinoma of LungLung NeoplasmsHumansLungNeoplasm InvasivenessNeoplasm Stagingadenocarcinoma in situground-glasslepidic patternlung biopsylung cancer

Identifiers

PMID35893116
PMCPMC9326548
OpenAlexW4283330627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.