Evidence map›Paper›PMID 35893070›Full record

ArticleGenes2022

Immune Transcriptome and Secretome Differ between Human CD71+ Erythroid Cells from Adult Bone Marrow and Fetal Liver Parenchyma.

Roman Perik-Zavodskii, Olga Perik-Zavodskaya, Yulia Shevchenko, Vera Denisova, Kirill Nazarov, Irina Obleuhova, Konstantin Zaitsev, Sergey Sennikov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Tumor-associated CD8Frontiers in immunology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Roman Perik-ZavodskiiLaboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Yadrincevskaya 14, Novosibirsk 630099, Russia.ORCID 0000-0002-5055-4859
Olga Perik-ZavodskayaLaboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Yadrincevskaya 14, Novosibirsk 630099, Russia.
Yulia ShevchenkoLaboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Yadrincevskaya 14, Novosibirsk 630099, Russia.
Vera DenisovaClinic of Immunopathology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Zalesskogo 2/1, Novosibirsk 630047, Russia.
Kirill NazarovLaboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Yadrincevskaya 14, Novosibirsk 630099, Russia.
Irina ObleuhovaLaboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Yadrincevskaya 14, Novosibirsk 630099, Russia.
Konstantin ZaitsevFederal State Budgetary Scientific Institution "Siberian Federal Research and Clinical Center of the Federal Medicobiological Agency", Rozy Lyuksemburg 5, Tomsk 634009, Russia.
Sergey SennikovLaboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Yadrincevskaya 14, Novosibirsk 630099, Russia.ORCID 0000-0002-7366-7768
Research Institute of Fundamental and Clinical Immunology · RUFederal Medical-Biological Agency · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD71+ erythroid cells (CECs) were only known as erythrocyte progenitors not so long ago. In present times, however, they have been shown to be active players in immune regulation, especially in immunosuppression by the means of ROS, arginase-1 and arginase-2 production. Here, we uncover organ-of-origin differences in cytokine gene expression using NanoString and protein production using Bio-Plex between CECs from healthy human adult bone marrow and from human fetal liver parenchyma. Namely, healthy human adult bone marrow CECs both expressed and produced IFN-a, IL-1b, IL-8, IL-18 and MIF mRNA and protein, while human fetal liver parenchymaCECs expressed and produced IFN-a, IL15, IL18 and TNF-b mRNA and protein. We also detected TLR2 and TLR9 gene expression in both varieties of CECs and TLR1 and NOD2 gene expression in human fetal liver parenchymaCECs only. These observations suggest that there might be undiscovered roles in immune response for CECs.

Indexed as

ArginaseBone MarrowAdultErythroid CellsHumansLiverRNA, MessengerSecretomeTranscriptomeArginaseRNA, Messengerbone marrowCD71+ erythroid cellsfetal liver parenchymaIL8MIFNOD2TLR1TLR2TLR9

Identifiers

PMID35893070
PMCPMC9330402
OpenAlexW4288041610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.