Evidence map›Paper›PMID 35893067›Full record

ArticleGenes2022

MicroRNA and MicroRNA-Target Variants Associated with Autism Spectrum Disorder and Related Disorders.

Anthony Wong, Anbo Zhou, Xiaolong Cao, Vaidhyanathan Mahaganapathy, Marco Azaro, Christine Gwin, Sherri Wilson, Steven Buyske, Christopher W Bartlett, Judy F Flax and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anthony WongDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Anbo ZhouDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Xiaolong CaoDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0001-8124-7491
Vaidhyanathan MahaganapathyDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0003-0577-2870
Marco AzaroDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Christine GwinDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Sherri WilsonDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Steven BuyskeDepartment of Statistics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0001-8539-5416
Christopher W BartlettThe Steve & Cindy Rasmussen Institute for Genomic Medicine, Battelle Center for Computational Biology, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.
Judy F FlaxDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Linda M BrzustowiczDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0003-4707-9441
Jinchuan XingDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0001-6469-8733
Rutgers, The State University of New Jersey · USNationwide Children's Hospital · US

Funding

Genetic Components of Autism Spectrum DisordersR01MH070366 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M · 2003 to 2007
$3.6M
Behavioral and Genetic Biomarker Development for Autism and Related DisordersRC1MH088288 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI BRZUSTOWICZ, LINDA M · 2009 to 2010
$994k
NIMH NIH HHS R01 MH070366NIMH NIH HHS RC1 MH088288
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a childhood neurodevelopmental disorder with a complex and heterogeneous genetic etiology. MicroRNA (miRNA), a class of small non-coding RNAs, could regulate ASD risk genes post-transcriptionally and affect broad molecular pathways related to ASD and associated disorders. Using whole-genome sequencing, we analyzed 272 samples in 73 families in the New Jersey Language and Autism Genetics Study (NJLAGS) cohort. Families with at least one ASD patient were recruited and were further assessed for language impairment, reading impairment, and other associated phenotypes. A total of 5104 miRNA variants and 1,181,148 3' untranslated region (3' UTR) variants were identified in the dataset. After applying several filtering criteria, including population allele frequency, brain expression, miRNA functional regions, and inheritance patterns, we identified high-confidence variants in five brain-expressed miRNAs (targeting 326 genes) and 3' UTR miRNA target regions of 152 genes. Some genes, such as

Indexed as

Autism Spectrum DisorderAutistic DisorderMicroRNAs3' Untranslated RegionsAllelesHumans3' Untranslated RegionsMicroRNAs3′ UTRautism spectrum disorderfamily cohortmiRNAneurodevelopmental disorderwhole-genome sequencing

Identifiers

PMID35893067
PMCPMC9329941
OpenAlexW4288041123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.