Evidence map›Paper›PMID 35893065›Full record

ArticleGenes2022

Genome-Wide Association Analysis for Chronic Superficial Keratitis in the Australian Racing Greyhound.

Steven Karamatic, Rebecca Goode, Niruba Bageswaran, Cali E Willet, Georgina Samaha, Ray Ferguson, Hamutal Mazrier, Claire M Wade

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. GWAS using low-pass whole genome sequence reveals a novel locus in canine congenital idiopathic megaesophagus.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Steven KaramaticGreyhound Racing Victoria, 46-50 Chetwynd Street, West Melbourne, VIC 3003, Australia.
Rebecca GoodeGreyhound Adoption Program, Greyhound Racing Victoria, 298 Goulburn Valley Hwy, Seymour, VIC 3660, Australia.
Niruba BageswaranFaculty of Science, School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW 2006, Australia.
Cali E WilletSydney Informatics Hub, The University of Sydney, Camperdown, NSW 2006, Australia.
Georgina SamahaSydney Informatics Hub, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0003-0419-1476
Ray FergusonAustralian Greyhound Working and Sporting Dog Veterinarians, 1662 Dandenong Road, East Oakleigh, VIC 3166, Australia.
Hamutal MazrierFaculty of Science, Sydney School of Veterinary Sciences, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0001-9769-5328
Claire M WadeFaculty of Science, School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0003-3413-4771
The University of Sydney · AURacing Victoria · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic superficial keratitis (CSK) is a progressive inflammatory condition of the eye (cornea) that can cause discomfort and blindness. Differential disease risk across dog breeds strongly suggests that CSK has a genetic basis. In addition to genetic risk, the occurrence of CSK is exacerbated by exposure to ultraviolet light. Genome-wide association analysis considered 109 greyhounds, 70 with CSK and the remainder with normal phenotype at an age over four years. Three co-located variants on CFA18 near the 5' region of the Epidermal Growth Factor Receptor (

Indexed as

Dog DiseasesKeratitisAnimalsAustraliaDogsErbB ReceptorsGenome-Wide Association StudyErbB Receptorschronic superficial keratitisEGFREpidermal Growth Factor Receptorgreyhoundpannus

Identifiers

PMID35893065
PMCPMC9332392
OpenAlexW4288041189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.