Evidence map›Paper›PMID 35892970›Full record

ReviewBiology2022

Association between Cervical Microbiota and HPV: Could This Be the Key to Complete Cervical Cancer Eradication?

Eliano Cascardi, Gerardo Cazzato, Antonella Daniele, Erica Silvestris, Gennaro Cormio, Giovanni Di Vagno, Antonio Malvasi, Vera Loizzi, Salvatore Scacco, Vincenzo Pinto and 6 more

Abstract readReview
In one paragraph

Review in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. iScience · 2025
    Article
  5. Review
  6. The "Magnificent Seven" in Oral and Systemic Health against COVID-19.Endocrine, metabolic & immune disorders drug targets · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
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  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Eliano CascardiDepartment of Medical Sciences, University of Turin, 10124 Turin, Italy.ORCID 0000-0003-1287-4285
Gerardo CazzatoDepartment of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Section, University of Bari "Aldo Moro", Piazza Aldo Moro, 70100 Bari, Italy.ORCID 0000-0003-0325-4316
Antonella DanieleExperimental Oncology, Center for Study of Heredo-Familial Tumors, IRCCS Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy.
Erica SilvestrisGynecologic Oncology Unit, IRCCS Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy.ORCID 0000-0001-7415-5986
Gennaro CormioGynecologic Oncology Unit, IRCCS Istituto Tumori Giovanni Paolo II, Department of Interdisciplinary Medicine (DIM), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-5745-372X
Giovanni Di VagnoClinic of Obstetrics and Gynecology, "San Paolo" Hospital, 70124 Bari, Italy.
Antonio MalvasiDepartment of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Section, University of Bari "Aldo Moro", Piazza Aldo Moro, 70100 Bari, Italy.
Vera LoizziGynecologic Oncology Unit, IRCCS Istituto Tumori Giovanni Paolo II, Department of Interdisciplinary Medicine (DIM), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-4006-6421
Salvatore ScaccoDepartment of Basic Medical Sciences and Neurosciences, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.ORCID 0000-0003-2717-2489
Vincenzo PintoDepartment of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Section, University of Bari "Aldo Moro", Piazza Aldo Moro, 70100 Bari, Italy.
Ettore CicinelliDepartment of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Section, University of Bari "Aldo Moro", Piazza Aldo Moro, 70100 Bari, Italy.
Eugenio MaioranoDepartment of Emergency and Organ Transplantation, Pathology Section, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.ORCID 0000-0002-0472-5338
Giuseppe IngravalloDepartment of Emergency and Organ Transplantation, Pathology Section, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.ORCID 0000-0002-4792-3545
Leonardo RestaDepartment of Emergency and Organ Transplantation, Pathology Section, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.ORCID 0000-0003-4335-4776
Carla MinoiaUnit of Hematology and Cell Therapy, Laboratory of Hematological Diagnostics and Cell Characterization, 70124 Bari, Italy.ORCID 0000-0002-5707-0689
Miriam DellinoDepartment of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Section, University of Bari "Aldo Moro", Piazza Aldo Moro, 70100 Bari, Italy.ORCID 0000-0003-3522-4648

Funding

(5x1000) from the IRCCS Istituto Tumori "Giovanni Paolo II" Bari 2021
6 · The paper itself

Abstract

The heterogeneity of the cervico-vaginal microbiota can be appreciated in various conditions, both pathological and non-pathological, and can vary according to biological and environmental factors. Attempts are still in course to define the interaction and role of the various factors that constitute this community of commensals in immune protection, inflammatory processes, and the onset of precancerous lesions of the cervical epithelium. Despite the many studies on the relationship between microbiota, immunity, and HPV-related cervical tumors, further aspects still need to be probed. In this review article, we will examine the principal characteristics of microorganisms commonly found in cervico-vaginal specimens (i) the factors that notoriously condition the diversity and composition of microbiota, (ii) the role that some families of organisms may play in the onset of HPV-dysplastic lesions and in neoplastic progression, and (iii) possible diagnostic-therapeutic approaches.

Indexed as

cervical cancercervical intraepithelial neoplasiacervical microbiotaCINmicrobiota

Identifiers

PMID35892970
PMCPMC9351688

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.