ReviewBiology2022
How Metabolic Rate Relates to Cell Size.
Review in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- 3D matrix stiffness drives energy metabolism to orchestrate stem cell osteogenesis via microtubule acetylation and mitochondrial dynamics.Bioactive materials · 2026Article
- Macroevolution of Steep Interspecific Metabolic Allometry in an Old Insect Order.Ecology letters · 2026Article
- Mitochondrial metabolic imbalance drives diploidization in mouse haploid embryonic stem cells via NADPH overload.Nature communications · 2026Article
- ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.Cell death discovery · 2026Article
- The "fire of life cycles": age-specific metabolic scaling within and among species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Review
- Co-variation and trade-offs in ontogenetic scaling of growth and metabolic rates in teleost fish.Communications biology · 2026Article
- Metabolic Consequences of Hybridization in European Water Frogs (Ecology and evolution · 2025Article
- Evolutionary diversity of muscle OXPHOS efficiencyProceedings. Biological sciences · 2025Article
- Mass scaling of standard metabolic rate within and among individuals in Western mosquitofish (Gambusia affinis).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Establishment of cell size-dependent growth rate via differential scaling of metabolite uptake and release.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Scaling of shoot and root respiration of woody and herbaceous plants.Proceedings. Biological sciences · 2025Article
- Ontogeny of energy use in harvester ant colonies, and the metabolic expense of colony growth.Proceedings. Biological sciences · 2025Article
- Eukaryotic cell size regulation and its implications for cellular function and dysfunction.Physiological reviews · 2024Review
- Article
- Interactive effects of intrinsic and extrinsic factors on metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Heat tolerance inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- A new mechanistic model for individual growth applied to insects under ad libitum conditions.PloS one · 2024Article
- The Relevance of Time in Biological Scaling.Biology · 2023Review
- Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators.Scientific reports · 2023Article
- Polyploidy in Xenopus lowers metabolic rate by decreasing total cell surface area.Current biology : CB · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic rate and its covariation with body mass vary substantially within and among species in little understood ways. Here, I critically review explanations (and supporting data) concerning how cell size and number and their establishment by cell expansion and multiplication may affect metabolic rate and its scaling with body mass. Cell size and growth may affect size-specific metabolic rate, as well as the vertical elevation (metabolic level) and slope (exponent) of metabolic scaling relationships. Mechanistic causes of negative correlations between cell size and metabolic rate may involve reduced resource supply and/or demand in larger cells, related to decreased surface area per volume, larger intracellular resource-transport distances, lower metabolic costs of ionic regulation, slower cell multiplication and somatic growth, and larger intracellular deposits of metabolically inert materials in some tissues. A cell-size perspective helps to explain some (but not all) variation in metabolic rate and its body-mass scaling and thus should be included in any multi-mechanistic theory attempting to explain the full diversity of metabolic scaling. A cell-size approach may also help conceptually integrate studies of the biological regulation of cellular growth and metabolism with those concerning major transitions in ontogenetic development and associated shifts in metabolic scaling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.