Evidence map›Paper›PMID 35892944›Full record

ArticleMarine drugs2022

Impact of Degree of Ionization and PEGylation on the Stability of Nanoparticles of Chitosan Derivatives at Physiological Conditions.

André Miguel Martinez Junior, Aline Margarete Furuyama Lima, Grazieli Olinda Martins, Vera Aparecida de Oliveira Tiera, Mohamed Benderdour, Julio Cesar Fernandes, Marcio José Tiera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Current gene therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

André Miguel Martinez JuniorDepartment of Chemistry and Environmental Sciences, IBILCE, São Paulo State University-UNESP, São José do Rio Preto 15054-000, SP, Brazil.
Aline Margarete Furuyama LimaDepartment of Chemistry and Environmental Sciences, IBILCE, São Paulo State University-UNESP, São José do Rio Preto 15054-000, SP, Brazil.
Grazieli Olinda MartinsDepartment of Chemistry and Environmental Sciences, IBILCE, São Paulo State University-UNESP, São José do Rio Preto 15054-000, SP, Brazil.
Vera Aparecida de Oliveira TieraDepartment of Chemistry and Environmental Sciences, IBILCE, São Paulo State University-UNESP, São José do Rio Preto 15054-000, SP, Brazil.
Mohamed BenderdourOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal-Canada, Montreal, QC H3C3J7, Canada.
Julio Cesar FernandesOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal-Canada, Montreal, QC H3C3J7, Canada.
Marcio José TieraDepartment of Chemistry and Environmental Sciences, IBILCE, São Paulo State University-UNESP, São José do Rio Preto 15054-000, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRHôpital du Sacré-Cœur de Montréal · CAUniversité de Montréal · CA

Funding

São Paulo Research Foundation 2017/10331.5
6 · The paper itself

Abstract

Nowadays, the therapeutic efficiency of small interfering RNAs (siRNA) is still limited by the efficiency of gene therapy vectors capable of carrying them inside the target cells. In this study, siRNA nanocarriers based on low molecular weight chitosan grafted with increasing proportions (5 to 55%) of diisopropylethylamine (DIPEA) groups were developed, which allowed precise control of the degree of ionization of the polycations at pH 7.4. This approach made obtaining siRNA nanocarriers with small sizes (100-200 nm), positive surface charge and enhanced colloidal stability (up to 24 h) at physiological conditions of pH (7.4) and ionic strength (150 mmol L

Indexed as

ChitosanNanoparticlesHeLa CellsHumansParticle SizePolyethylene GlycolsRNA, Small InterferingChitosanPolyethylene GlycolsRNA, Small InterferingDIPEAgene therapynanoparticlesphysiological pHsiRNA

Identifiers

PMID35892944
PMCPMC9330794
OpenAlexW4287832762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.