Evidence map›Paper›PMID 35892900›Full record

ArticleCancers2022

Novel Dicarboximide BK124.1 Breaks Multidrug Resistance and Shows Anticancer Efficacy in Chronic Myeloid Leukemia Preclinical Models and Patients' CD34

Iga Stukan, Marek Gryzik, Grażyna Hoser, Andrew Want, Wioleta Grabowska-Pyrzewicz, Mikolaj Zdioruk, Mariola Napiórkowska, Marcin Cieślak, Karolina Królewska-Golińska, Barbara Nawrot and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Iga StukanLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.ORCID 0000-0003-3560-6339
Marek GryzikLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.
Grażyna HoserLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.ORCID 0000-0002-0917-5611
Andrew WantLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.ORCID 0000-0001-7800-873X
Wioleta Grabowska-PyrzewiczLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.
Mikolaj ZdiorukLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.
Mariola NapiórkowskaDepartment of Biochemistry, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-1174-2208
Marcin CieślakCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Lodz, Poland.ORCID 0000-0002-9628-214X
Karolina Królewska-GolińskaCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Lodz, Poland.ORCID 0000-0002-2979-8867
Barbara NawrotCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Lodz, Poland.ORCID 0000-0002-4084-4334
Grzegorz BasakDepartment of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-3858-8180
Urszula WojdaLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.ORCID 0000-0002-4525-2004
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLCentrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk · PLMedical University of Warsaw · PL

Funding

National Science Center OPUS8 2014/15/B/NZ7/00966
6 · The paper itself

Abstract

The search is ongoing for new anticancer therapeutics that would overcome resistance to chemotherapy. This includes chronic myeloid leukemia, particularly suitable for the studies of novel anticancer compounds due to its homogenous and well-known genetic background. Here we show anticancer efficacy of novel dicarboximide denoted BK124.1 (C

Indexed as

apoptosiscancerchemotherapychronic myeloid leukemiadrug resistanceleukemia stem cellsMDR1multidrug resistancenovel therapyP-glycoprotein

Identifiers

PMID35892900
PMCPMC9332833
OpenAlexW4288034055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.