Evidence map›Paper›PMID 35892838›Full record

ArticleCancers2022

Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component.

Mayu Ueda, Katsuya Matsuda, Hirokazu Kurohama, Zhanna Mussazhanova, Yerkezhan Sailaubekova, Hisayoshi Kondo, Tomoki Shimizu, Nami Takada, Yuki Matsuoka, Chieko Otsubo and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Mayu UedaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Katsuya MatsudaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.ORCID 0000-0001-7345-2014
Hirokazu KurohamaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Zhanna MussazhanovaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Yerkezhan SailaubekovaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Hisayoshi KondoBiostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.
Tomoki ShimizuMedical Student Research Program, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan.
Nami TakadaMedical Student Research Program, Oita University School of Medicine, Oita 879-5593, Japan.
Yuki MatsuokaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Chieko OtsuboDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Shinya SatoYamashita Thyroid Hospital, Fukuoka 812-0034, Japan.
Hiroyuki YamashitaYamashita Thyroid Hospital, Fukuoka 812-0034, Japan.
Atsushi KawakamiDepartment of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Masahiro NakashimaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.ORCID 0000-0002-9036-8735
Nagasaki University · JPYamashita Thyroid HospitalAl-Farabi Kazakh National University · KZNagasaki University Hospital · JPOita University · JP

Funding

the Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture 20K07424the Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture 24590414the Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture 26461951
6 · The paper itself

Abstract

Thyroid follicular-patterned tumors (TFTs) showing nodule-in-nodule (NN) appearance with poorly differentiated component (PDc) but neither invasion nor metastasis are diagnosed as benign nodules. Although PDc exhibits histologically aggressive features relative to the outer nodule (Out-N), its pathological significance remains unclear. TP53 binding protein-1 (53BP1) is a DNA damage response (DDR) molecule that rapidly localizes at DNA double-strand breaks. Using dual-color immunofluorescence with Ki-67, the profile of 53BP1 expression is shown to be significantly altered during diverse tumorigenesis. In this study, we aimed to elucidate the malignant potential of PDc at the molecular level. We analyzed the profile of 53BP1 expression and

Indexed as

53BP1DNA damage responsegenomic instabilityimmunofluorescenceKi-67nodule-in-noduleNRASpoorly differentiated componentthyroid

Identifiers

PMID35892838
PMCPMC9331311
OpenAlexW4286586561

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.