Evidence map›Paper›PMID 35892822›Full record

ReviewCancers2022

How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity.

Martina Chirra, Hannah S Newton, Vaibhavkumar S Gawali, Trisha M Wise-Draper, Ameet A Chimote, Laura Conforti

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. NaFrontiers in chemistry · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. High Extracellular KEuropean journal of immunology · 2025
    Article
  10. Review
  11. Article
  12. Metal-based smart nanosystems in cancer immunotherapy.Exploration (Beijing, China) · 2024
    Review
  13. SubvertingBiology · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Activity of Potassium Channels in CD8International journal of molecular sciences · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Martina ChirraDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Hannah S NewtonDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-6368-0803
Vaibhavkumar S GawaliDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-7917-4913
Trisha M Wise-DraperDivision of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Ameet A ChimoteDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0001-5163-0123
Laura ConfortiDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-3761-7595
University of Cincinnati · US

Funding

Training Program in Cancer TherapeuticsT32CA117846 · NCI · UNIVERSITY OF CINCINNATI · PI PRICE, CAROLYN M, TAKIAR, VINITA · 2006 to 2022
$6.5M
Hypoxia and Potassium Channel Activity in T LymphocytesR01CA095286 · NCI · UNIVERSITY OF CINCINNATI · PI CONFORTI, LAURA · 2003 to 2019
$4.1M
Stimulating Access to Research in the University of Cincinnati Internal Medicine Residency ProgramR38HL155775 · NHLBI · UNIVERSITY OF CINCINNATI · PI Jack Rubinstein · 2021 to 2026
$1.6M
NCI NIH HHS R01 CA095286NCI NIH HHS R01-CA95286NIH HHS R38HL155775 01NIH HHS T32 CA117846United States Department of Defense W81XWH-17-1-0374
6 · The paper itself

Abstract

Competent antitumor immune cells are fundamental for tumor surveillance and combating active cancers. Once established, tumors generate a tumor microenvironment (TME) consisting of complex cellular and metabolic elements that serve to suppress the function of antitumor immune cells. T lymphocytes are key cellular elements of the TME. In this review, we explore the role of ion channels, particularly K

Indexed as

antitumor immunityion channelspotassium channelstumor microenvironment

Identifiers

PMID35892822
PMCPMC9330401
OpenAlexW4286587280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.