Evidence map›Paper›PMID 35892582›Full record

ArticleCells2022

Human Palatine Tonsils Are Linked to Alzheimer's Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection.

Jung Yeon Lim, Jung Eun Lee, Han Kyung Kim, Yeon-Joon Park, Jung Ho Jeon, Soon-A Park, Naeun Lee, Il Hwan Lee, Do Hyun Kim, Seung Ho Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jung Yeon LimDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Jung Eun LeeDepartment of Neurosurgery, St. Vincent Hospital, The Catholic University of Korea, Suwon 16247, Korea.
Han Kyung KimDepartment of Microbiology, CHA University School of Medicine, Seongnam 13415, Korea.
Yeon-Joon ParkDepartment of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Jung Ho JeonDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Soon-A ParkDepartment of Neurosurgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Naeun LeeCenter for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul 06591, Korea.
Il Hwan LeeDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Do Hyun KimDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Seung Ho YangDepartment of Neurosurgery, St. Vincent Hospital, The Catholic University of Korea, Suwon 16247, Korea.ORCID 0000-0002-3490-1064
Jongman YooDepartment of Microbiology, CHA University School of Medicine, Seongnam 13415, Korea.
Sung Won KimDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
The Catholic University of Korea Seoul St. Mary's Hospital · KRCHA University · KRThe Catholic University of Korea St. Vincent's Hospital · KRCatholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid-β (Aβ)-peptide production or deposition in the neuropathology of Alzheimer's disease (AD) was shown to be caused by chronic inflammation that may be induced by infection, but the role of pathogenic-bacteria-related AD-associated Aβ is not yet clearly understood. In this study, we validated the hypothesis that there is a correlation between the Aβ-protein load and bacterial infection and that there are effects of bacteria,

Indexed as

Alzheimer DiseaseBacterial InfectionsAmyloid beta-PeptidesHumansPalatine TonsilStaphylococcus aureusAmyloid beta-Peptidesamyloid betabrain organoidhuman palatine tonsilStaphylococcus aureustonsil organoid

Identifiers

PMID35892582
PMCPMC9330135
OpenAlexW4287009168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.