Evidence map›Paper›PMID 35892580›Full record

ArticleCells2022

Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease.

Haroon Arshad, Anastasios Siokis, Raimo Franke, Aamna Habib, Juan Carlos López Alfonso, Yuliya Poliakova, Eva Lücke, Katina Michaelis, Mark Brönstrup, Michael Meyer-Hermann and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Kynurenine Pathway in Respiratory Diseases.International journal of tryptophan research : IJTR · 2024
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Haroon ArshadResearch Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.
Anastasios SiokisDepartment of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0003-4695-0354
Raimo FrankeDepartment of Chemical Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0002-5407-5521
Aamna HabibDepartment of Chemical Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Juan Carlos López AlfonsoDepartment of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Yuliya PoliakovaDepartment of Clinical Microbiology, Biomedical Diagnostic Centre (CDB), Hospital Clinic, School of Medicine, University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-2716-4729
Eva LückeClinic for Pneumology, Otto-von-Guericke University, 39106 Magdeburg, Germany.
Katina MichaelisClinic for Pneumology, Otto-von-Guericke University, 39106 Magdeburg, Germany.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0002-8971-7045
Michael Meyer-HermannDepartment of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0002-4300-2474
Ursula BilitewskiDepartment of Chemical Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0003-2952-1208
Jordi VilaDepartment of Clinical Microbiology, Biomedical Diagnostic Centre (CDB), Hospital Clinic, School of Medicine, University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-8025-3926
Laurent AbelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, 75015 Paris, France.
Thomas IlligHannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.
Jens SchreiberClinic for Pneumology, Otto-von-Guericke University, 39106 Magdeburg, Germany.
Frank PesslerResearch Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.ORCID 0000-0002-3434-2311
Helmholtz Centre for Infection Research · DEOtto-von-Guericke-Universität Magdeburg · DEUniversitat de Barcelona · ESInserm · FRMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amino acids and their metabolites are key regulators of immune responses, and plasma levels may change profoundly during acute disease states. Using targeted metabolomics, we evaluated concentration changes in plasma amino acids and related metabolites in community-acquired pneumonia (CAP,

Indexed as

Community-Acquired InfectionsPneumoniaPulmonary Disease, Chronic ObstructiveAsparagineBiomarkersConvalescenceHumansKynurenineThreonineTryptophanAsparagineBiomarkersKynurenineThreonineTryptophanamino acidsbiogenic aminesbiomarkerschronic obstructive pulmonary diseasediagnosisinflammationmetabolismpathogenesispneumoniaStaphylococcus aureus

Identifiers

PMID35892580
PMCPMC9330610
OpenAlexW4287009732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.