Evidence map›Paper›PMID 35892578›Full record

ArticleCells2022

BzATP Activates Satellite Glial Cells and Increases the Excitability of Dorsal Root Ganglia Neurons In Vivo.

Zhiyong Chen, Chi Zhang, Xiaodan Song, Xiang Cui, Jing Liu, Neil C Ford, Shaoqiu He, Guangwu Zhu, Xinzhong Dong, Menachem Hanani and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. P2X7 and P2YPurinergic signalling · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Brain communications · 2024
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Zhiyong ChenDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-0475-3491
Chi ZhangDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xiaodan SongDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xiang CuiDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-3029-5829
Jing LiuDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Neil C FordDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Shaoqiu HeDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Guangwu ZhuDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xinzhong DongThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Menachem HananiLaboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91240, Israel.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1321-6655
Johns Hopkins University · USHebrew University of Jerusalem · ILHoward Hughes Medical Institute · US

Funding

Birth Tissue Products for Non-opioid Treatment of Post-surgical PainR01NS117761 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2020 to 2024
$2.6M
Mechanistic Study of Pain Inhibition by Activation of Non-nociceptive Afferent FibersR01NS110598 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2019 to 2024
$2.4M
NINDS NIH HHS R01 NS110598NINDS NIH HHS R01 NS117761
6 · The paper itself

Abstract

The purinergic system plays an important role in pain transmission. Recent studies have suggested that activation of P2-purinergic receptors (P2Rs) may be involved in neuron-satellite glial cell (SGC) interactions in the dorsal root ganglia (DRG), but the details remain unclear. In DRG, P2X7R is selectively expressed in SGCs, which closely surround neurons, and is highly sensitive to 3'-O-(4-Benzoyl) benzoyl-ATP (BzATP). Using calcium imaging in intact mice to survey a large number of DRG neurons and SGCs, we examined how intra-ganglionic purinergic signaling initiated by BzATP affects neuronal activities in vivo. We developed

Indexed as

CalciumGanglia, SpinalAdenosine TriphosphateAnimalsMiceNeurogliaNeurons3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateAdenosine TriphosphateCalciumcalcium imagingdorsal root ganglionmicepainpurinergic receptorsatellite glial cell

Identifiers

PMID35892578
PMCPMC9330736
OpenAlexW4287009828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.