A Simplified Murine Model to Imitate Flexor Tendon Adhesion Formation without Suture.

Rong Bao, Shi Cheng, Jianyu Zhu, Feng Hai, Wenli Mi, Shen Liu

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Article in Biomimetics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rong BaoDepartment of Orthopaedics, Sixth People's Hospital, Jiao Tong University, 600 Yishan Rd, Shanghai 200233, China.

Shi ChengDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Jianyu ZhuDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Feng HaiDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Wenli MiDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Shen LiuDepartment of Orthopaedics, Sixth People's Hospital, Jiao Tong University, 600 Yishan Rd, Shanghai 200233, China.ORCID 0000-0002-4214-688X

Shanghai Medical College of Fudan University · CNShanghai Sixth People's Hospital · CN

Funding

National Natural Science Foundation of China 81772314National Natural Science Foundation of China 81922045National Natural Science Foundation of China 82172408Original Exploration project 22ZR1480300Outstanding Academic Leaders (Youth) project 21XD1422900Principle Investigator Innovation Team of Both Shanghai Sixth People's Hospital and Shanghai Institute of Nutrition and Health, Shanghai Jiao Tong University Medical College "Two-hundred Talent" Program No.20191829"Qingfeng Scholar" for student Scientific Research Program of Shanghai Medical College, Fudan University QF 1918Shanghai Excellent Academic Leader Program; and Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration No.20DZ2254100The Second Three-Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals of Shanghai Shenkang No.SHDC2020CR4032

6 · The paper itself

Abstract

Peritendinous adhesion (PA) around tendons are daunting challenges for hand surgeons. Tenotomy with various sutures are considered classical tendon repair models (TRM) of tendon adhesion as well as tendon healing. However, potential biomimetic therapies such as anti-adhesion barriers and artificial tendon sheaths to avoid recurrence of PA are sometimes tested in these models without considering tendon healing. Thus, our aim is to create a simplified model without sutures in this study by using three 6 mm longitudinal and parallel incisions called the longitudinal incision model (LCM) in the murine flexor tendon. We found that the adhesion score of LCM has no significant difference to that in TRM. The range of motion (ROM) reveals similar adhesion formation in both TRM and LCM groups. Moreover, mRNA expression levels of collagen I and III in LCM shows no significant difference to that in TRM. The breaking force and stiffness of LCM were significantly higher than that of TRM. Therefore, LCM can imitate flexor tendon adhesion formation without sutures compared to TRM, without significant side effects on biomechanics with an easy operation.

Indexed as

biomechanicscollagen depositionflexor tendontendon adhesion

Identifiers

PMID35892362

DOI10.3390/biomimetics7030092

PMCPMC9326731

OpenAlexW4284707474

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.