ReviewBiomimetics (Basel, Switzerland)2022
The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review.
Review in Biomimetics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
230 citing papers in PubMed.
- Efficacy and safety of RD2 Ver.02, a whole blood clot therapy, coupled with a minimally invasive procedure in pilonidal sinus: a phase II study.Techniques in coloproctology · 2024Trial
- Green tea and hyaluronic acid gel enhance fibroblast activation and improves the gingival healing post-third molar extraction.Scientific reports · 2024Trial
- Supramolecular engineering of fibrinogen into a fibrin matrix with enhanced bioactive properties.Bioactive materials · 2027Article
- Ameliorative effects ofMolecular medicine reports · 2026Article
- Review
- Inflammasome-derived biomarkers in wound healing: linking tissue repair, chronic inflammation, fibrosis, and precision therapeutics.Molecular biology reports · 2026Review
- Review
- Extracellular Matrix Remodeling in Tumors: Forces Beyond Fibroblasts.Cancer research · 2026Article
- Clinical and Radiographic Evaluation of Plasma Rich in Growth Factors (PRGF) for Alveolar Ridge Preservation in the Anterior Maxilla.Journal of functional biomaterials · 2026Article
- Cytological Performance Evaluation of a Novel Skin-Repair Agent: Recombinant Protein Disulfide Bond Isomerase.Bioengineering (Basel, Switzerland) · 2026Article
- Developing an Analytical Framework for the Molecular Weight Analysis of Fish-Derived Collagen Peptides in Beverages: A Multi-Method Comparative Study.Food science & nutrition · 2026Article
- Bilayer tri-dermal-network hydrogel for sequential delivery of PD-168077 in multimodal diabetic wound regeneration.Bioactive materials · 2026Article
- Full-Length Laminin-332 Promotes Integrin α3β1-Dependent Cutaneous Wound Closure in a Murine Model.Biomedicines · 2026Article
- Mechanistic Pathways of Wound Healing: From Hemostasis to Scar-Free Regeneration.Cell biochemistry and function · 2026Review
- Callus Induction inPlants (Basel, Switzerland) · 2026Article
- Regenerative Performance and Structural Persistence of Silk Fibroin Matrices in Human Infected and Non-Infected Ex Vivo Wounds.Biomimetics (Basel, Switzerland) · 2026Article
- Sepsis-induced endothelial glycocalyx disruption and remodeling: an ultrastructural study in mice.Intensive care medicine experimental · 2026Article
- Hidradenitis suppurativa: epidemiology, diagnosis, molecular pathogenesis and therapy.Molecular biomedicine · 2026Review
- Review
- Engineering in vitro models to replicate the complexity of chronic wounds.Nature communications · 2026Review
170 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It is comprised of varying proteins, including collagens, elastin, and smaller quantities of structural proteins. Studies have demonstrated the ECM aids in cellular adherence, tissue anchoring, cellular signaling, and recruitment of cells. During times of integumentary injury or damage, either acute or chronic, the ECM is damaged. Through a series of overlapping events called the wound healing phases-hemostasis, inflammation, proliferation, and remodeling-the ECM is synthesized and ideally returned to its native state. This article synthesizes current and historical literature to demonstrate the involvement of the ECM in the varying phases of the wound healing cascade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.